Co-Printing of Vertical Axis Aligned Micron-Scaled Filaments Via Simultaneous Dual Needle Electrohydrodynamic Printing
In this study dual-needle electrohydrodynamic co-printing (DN-EHDCP) was developed to fabricate unique micron-scaled architectures based on multi-material ﬁbrous (ﬁlamentous) morphologies. Two stainless steel needles (contributing towards dual needle design) were used to simultaneously co-print poly(ɛ-caprolactone) (PCL) and polyvinylpyrrolidone (PVP) polymers (using solvent based formulations including Fe 3 O 4 nano- particles and active pharmaceutical ingredient (API). Diﬀerences in polymer hydrophobicity and dissolution rate were used to modulate drug release (tetracycline hydrochloride, TE-HCL) from various co-printed conﬁgura- tions. Optical, scanning electron and ﬂuorescent microscopy conﬁrmed precision alignment and vertical stacking of both PVP and PCL printed ﬁ laments. Process parameters were found to strongly inﬂuence co-print construct diameter. Fourier Transform Infrared (FTIR) spectroscopy conﬁrmed spatial locations of both PVP and PCL ﬁlaments. TE-HCL release from co-printed formulations exhibited two phases; rapid and sustained. In vitro biological assay (using L929 cell lines) demonstrated construct biocompatibility. However, selective integration (spatial and quantity) of sacriﬁcial PVP ﬁbers (after rapid dissolution) provided a method of in situ void en- gineering for enhanced interfacial interaction for remaining PCL structures. The present study shows the de- velopment and use of simultaneously co-printed ﬁlaments in the vertical axis with potential to control drug release through alignment of individual ﬁlaments and material type. Furthermore, the use of composite matrix under an external stimulus is also demonstrated indicating multiple approaches to modulate API release
The file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link.
Citation : Wang, B., Wu, S., Ahmad, Z., Li, J., Chang, M. (2018) Co-Printing of Vertical Axis Aligned Micron-Scaled Filaments Via Simultaneous Dual Needle Electrohydrodynamic Printing. European Polymer Journal, 104, pp 81-89.
ISSN : 0014-3057
Research Group : Pharmaceutical Technologies
Research Institute : Leicester Institute for Pharmaceutical Innovation - From Molecules to Practice (LIPI)
- Leicester School of Pharmacy