New Hydrogels Enriched with Antioxidants from Saffron Crocus Can Find Applications in Wound Treatment and/or Beautification

Date
2018-02
Authors
Zeka, K.
Ruparelia, K. C.
Sansone, C.
Macchiarelli, G.
Continenza, M. A.
Arroo, R. R. J.
Journal Title
Journal ISSN
ISSN
1660-5527
Volume Title
Publisher
Karger
Peer reviewed
Yes
Abstract
Saffron extracts have a long history of application as skin protectant, possibly due to their ability to scavenge free radicals. In this work, the performance of a hydrogel enriched with antioxidant compounds isolated from saffron crocus (Crocus sativus L.) petals was tested. These hydrogels could be considered as new drug delivery system. Hydrogels are crosslinked polymer networks that absorb large quantities of water but retain the properties of a solid, thus making ideal dressings for sensitive skin. We tested antioxidant-en- riched hydrogels on primary mouse fibroblasts. Hydrogels enriched with kaempferol and crocin extracted from saffron petals showed good biocompatibility with in vitro cultured fibroblasts. These new types of hydrogels may find applications in wound treatment and/or beautification.
Description
The file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link
Keywords
Crocus sativus, Drug delivery, Kaempferol, crocin, hydrogel, saffron
Citation
Zeka, K., Ruparelia, K.C., Sansone, C., Macchiarelli, G., Continenza, M.A., Arroo, R.R.J. (2018) New Hydrogels Enriched with Antioxidants from Saffron Crocus Can Find Applications in Wound Treatment and/or Beautification. Skin Pharmacology and Physiology. 31(2), pp.95-98.
Research Institute
Leicester Institute for Pharmaceutical Innovation - From Molecules to Practice (LIPI)