Contralateral Cerebro-Cerebellar White Matter Pathways for Verbal Working Memory: A Combined Diffusion Spectrum Imaging and fMRI Study

Date
2016-05
Authors
Sobczak-Edmans, M.
Lo, Y.-C.
Hsu, Y.-C.
Chen, Y.-J.
Kwok, F.Y.
Chuang, K. H.
Tseng, W.-Y.
Chen, S. H. A.
Journal Title
Journal ISSN
ISSN
DOI
Volume Title
Publisher
24th ISMRM Conference
Peer reviewed
Abstract
Diffusion spectrum imaging was employed to establish structural connectivity between cerebro-cerebellar regions co-activated during verbal working memory. IFG, IPL, pons, thalamus, superior cerebellum and inferior cerebellum were used as seed points to reconstruct the white matter cerebro-cerebellar circuitry. The reconstructed pathways were examined further to establish the relationship between structural and effective connectivity as well as the relationship between structural connectivity and verbal working memory performance. It was found that structural connectivity is indirectly related to effective connectivity but does not predict it. Additionally, it was demonstrated that the integrity of the ponto-cerebellar tract is an important factor in explaining individual differences in verbal working memory. The findings of the study furthered our understanding of the relationship between structural and functional connectivity and provided insight to the variability in verbal working memory performance.
Description
Keywords
neuroimaging, DSI, Cerebra-Cerebellar pathways,, working memory
Citation
Sobczak-Edmans, M. et al. (2016) Contralateral cerebro-cerebellar white matter pathways for verbal working memory: A combined diffusion spectrum imaging and fMRI study. Presented at the 24th ISMRM Conference, Singapore.
Research Institute
Institute for Psychological Science