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dc.contributor.authorDa Boit, Mariasoleen
dc.contributor.authorSibson, Rachaelen
dc.contributor.authorMeakin, Judith R.en
dc.contributor.authorAspden, Richard M.en
dc.contributor.authorThies, Franken
dc.contributor.authorMangoni, Arduino A.en
dc.contributor.authorGray, Stuart R.en
dc.identifier.citationDa Boit, M. et al. (2016) Sex differences in the response to resistance exercise training in older people. Physiological Reports, 4, e12834en
dc.descriptionOpen Access articleen
dc.description.abstractResistance exercise training is known to be effective in increasing muscle mass in older people. Acute measurement of protein metabolism data has indicated that the magnitude of response may differ between sexes. We compared adaptive responses in muscle mass and function to 18 weeks resistance exercise training in a cohort of older (>65 years) men and women. Resistance exercise training improved knee extensor maximal torque, 4 m walk time, time to complete five chair rises, muscle anatomical cross‐sectional area (ACSA) and muscle quality with no effect on muscle fat/water ratio or plasma glucose, insulin, triacylglycerol, IL‐6, and TNF‐α. Differences between sexes were observed for knee extensor maximal torque and muscle quality with greater increases observed in men versus women (P < 0.05). Maximal torque increased by 15.8 ± 10.6% in women and 41.7 ± 25.5% in men, whereas muscle quality increased by 8.8 ± 17.5% in women and by 33.7 ± 25.6% in men. In conclusion, this study has demonstrated a difference in the magnitude of adaptation, of some of the outcome measures employed, in response to 18 weeks of resistance exercise training between men and women. The mechanisms underlying this observation remain to be established.en
dc.publisherThe American Physiological Society and The Physiological Societyen
dc.subjectresistance exerciseen
dc.subjectolder peopleen
dc.subjectskeletal muscleen
dc.titleSex differences in the response to resistance exercise training in older peopleen
dc.exception.reasonopen access articleen
dc.researchinstituteInstitute for Allied Health Sciences Researchen

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