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dc.contributor.authorHasa, Dritanen
dc.contributor.authorGiacobbe, Carlottaen
dc.contributor.authorPerissutti, Beatriceen
dc.contributor.authorVoinovich, Darioen
dc.contributor.authorGrassi, Marioen
dc.contributor.authorCervellino, Antonioen
dc.contributor.authorMasciocchi, Norbertoen
dc.contributor.authorGuagliardi, Antoniettaen
dc.date.accessioned2017-04-25T09:43:29Z
dc.date.available2017-04-25T09:43:29Z
dc.date.issued2016-07-18
dc.identifier.citationHasa, D. et al. (2016) Nanostructured Drugs Embedded into a Polymeric Matrix: Vinpocetine/PVP Hybrids Investigated by Debye Function Analysis. molecular pharmaceutics, 13 (9), pp. 3034-3042en
dc.identifier.urihttp://hdl.handle.net/2086/14094
dc.descriptionThe file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link.en
dc.description.abstractMicrocrystalline vinpocetine, coground with cross-linked polyvinylpyrrolidone, affords hybrids containing nanosized drug nanocrystals, the size and size distributions of which depend on milling times and drug-to-polymer weight ratios. Using an innovative approach to microstructural characterization, we analyzed wide-angle X-ray total scattering data by the Debye function analysis and demonstrated the possibility to characterize pharmaceutical solid dispersions obtaining a reliable quantitative view of the physicochemical status of the drug dispersed in an amorphous carrier. The microstructural properties derived therefrom have been successfully employed in reconciling the enigmatic difference in behavior between in vitro and in vivo solubility tests performed on nanosized vinpocetine embedded in a polymeric matrix.en
dc.language.isoenen
dc.publisherACS Publicationsen
dc.subjectmechanical activationen
dc.subjectsolid dispersionen
dc.subjecttotal scatteringen
dc.subjectDebye scattering equationen
dc.subjectvinpocetineen
dc.titleNanostructured Drugs Embedded into a Polymeric Matrix: Vinpocetine/PVP Hybrids Investigated by Debye Function Analysisen
dc.typeArticleen
dc.identifier.doihttp://dx.doi.org/10.1021/acs.molpharmaceut.6b00124
dc.peerreviewedYesen
dc.funderN/Aen
dc.projectidN/Aen
dc.cclicenceCC-BY-NCen
dc.researchinstituteLeicester Institute for Pharmaceutical Innovation - From Molecules to Practice (LIPI)en
dc.exception.ref2021codes254aen


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