Actinometric and Φ-order photodegradation properties of anti-cancer Sunitinib.
The photodegradation reaction of Sunitinib (SUT), occurring via Z–E photoisomerization, has been evaluated in this study using the recently developed –order kinetics. In ethanol, the forward (Z E) photoreaction of SUT was invariant with irradiation (its quantum yield, 0.019) in contrast to the E Z isomerisation whose undergoes a 30‐fold, sigmoid–shaped, increase with increasing irradiation wavelength. This situation limited usefully the extent of Z– SUT photodegradation at the photostationary state to a maximum of c.a. 30 % of the initial concentration. Nevertheless, these results support a strong recommendation for a complete protection of SUT from light at all stages. Furthermore, a SUT‐actinometer was developed and was proven to be useful for the 320–480 nm spectral range. The latter wavelength interval defined as well SUT photodegradation causative range. The formalism of –order kinetics, proves to be a useful investigative tool for drugs’ photodegradation studies.
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Citation : Maafi, M. and Lee, L.Y. (2015) Actinometric and Φ-order photodegradation properties of anti-cancer Sunitinib. Journal of pharmaceutical and biomedical analysis, 110, pp. 34-41
Research Institute : Leicester Institute for Pharmaceutical Innovation - From Molecules to Practice (LIPI)
Peer Reviewed : Yes
- Leicester School of Pharmacy