Synthesis and antitrypanosomal activities of novel pyridylchalcones
A library of novel pyridylchalcones were synthesised and screened against Trypanosoma brucei rhodesiense. Eight were shown to have good activity with the most potent 8 having an IC50 value of 0.29 M. Cytotoxicity testing with human KB cells showed a good selectivity profile for this compound with a selectivity index of 47. Little activity was seen when the library was tested against Leishmania donovani. In conclusion, pyridylchalcones are promising leads in the development of novel compounds for the treatment of human African trypanosomiasis (HAT).
Collaboration with the London School of Hygiene and Tropical Medicine. The file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link.
Citation : Bhambra, A.S et al. (2017) Synthesis and antitrypanosomal activities of novel pyridylchalcones. European Journal of Medicinal Chemistry, 128, pp. 213-218
ISSN : 0223-5234
Peer Reviewed : Yes
- Leicester School of Pharmacy