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    Browsing Leicester School of Pharmacy by Title

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      • 1H NMR investigations of the molecular nature of cobalt (II) ions in human saliva 

        Chang, H.; Tomoda, S.; Silwood, C.; Lynch, E.; Grootveld, M. (Article)
        High-resolution 1H NMR spectroscopy demonstrated that addition of Co(II) ions to isolated human salivary supernatants (HSSs) gave rise to its complexation by a variety of biomolecules. The relative efficacies of these ...
      • 1H NMR-based metabolomics reveals neurochemical alterations in the brain of adolescent rats following acute methylphenidate administration 

        Quansah, Emmanuel; Ruiz-Rodado, Victor; Grootveld, M.; Probert, Fay; Zetterstrom, T. S. C. (Article)
        The psychostimulant methylphenidate (MPH) is increasingly used in the treatment of attention deficit hyperactivity disorder (ADHD). While there is little evidence for common brain pathology in ADHD, some studies suggest a ...
      • 1H NMR-Linked Metabolomics Analysis of Liver from a Mouse Model of NP-C1 Disease 

        Ruiz-Rodado, Victor; Nicoli, Elena-Raluca; Probert, Fay; Smith, David A.; Morris, Lauren; Wassif, Christopher A.; Platt, Frances M.; Grootveld, M. (Article)
      • 1H NMR-Linked Urinary Metabolic Profiling of Niemann-Pick Class C1 (NPC1) Disease: Identification of Potential New Biomarkers using Correlated Component Regression (CCR) and Genetic Algorithm (GA) Analysis Strategies 

        Ruiz-Rodado, Victor; Luque-Baena, R. M.; te Vruchte, D. J.; Probert, Fay; Lachmann, R. H.; Hendriksz, Christian J.; Wraith, James E.; Imrie, Jackie; Elizondo, David; Sillence, Daniel J.; Clayton, P.; Platt, Frances M.; Grootveld, M. (Article)
        Niemann-Pick Class 1 (NPC1) disease is a rare, debilitating neurodegenerative lysosomal storage disease; however, urinary biomarkers available for it and its prognosis are currently limited. In order to identify and establish ...
      • 2-furyl(phenyl)methanol isolated from Atractilis gummifera rhizome exhibits anti-leishmanial activity 

        Deiva, Solene; Ferguson, Lindsay; Rateb, Mostafa; Williams, Roderick; Brucoli, Federico (Article)
        We report for the first time the isolation of 2-furyl(phenyl)methanol (5) from the chloroform extracts of the Atractylis gummifera roots. A. gummifera is a thistle belonging to the Asteraceae family that produces the ...
      • 2-Oxothiazolidine-4-carboxylic acid inhibits vascular calcification via induction of glutathione synthesis 

        Baydoun, Anwar; Patel, J.J.; Bourne, L.E.; Thakur, S.; Farrington, K.; Gorog, D.A.; Orriss, I.R. (Article)
        Arterial medial calcification (AMC), the deposition of hydroxyapatite in the medial layer of the arteries, is a known risk factor for cardiovascular events. Oxidative stress is a known inducer of AMC and endogenous ...
      • 3D Electrohydrodynamic Printing of Highly Aligned Dual-Core Graphene Composite Matrices 

        Ahmad, Zeeshan; Wang, Baolin; Chen, Xing; Huang, Jie; Chang, Ming-Wei (Article)
        The aim of this study was to develop an EHD printing method to fabricate graphene-loaded polycaprolactone (PCL)/polyethylene oxide (PEO) dual-core matrices. Graphene was incorporated in shell PCL components, while gelatin ...
      • Absorption, Distribution, Metabolism and Excretion (ADME) of Dietary Flavones and Their Glycosides 

        Arroo, Randolph R.J. (Conference)
        Epidemiological studies have long indicated a possible role for dietary flavonoids, notably flavones and flavonols, in the prevention of a range of degenerative diseases, e.g. cancer, diabetes, cardiovascular diseases and ...
      • Accumulation of glycosphingolipids in Niemann-Pick C disease disrupts endosomal transport. 

        Sillence, Daniel J.; Lloyd-Evans, E.; Veldman, R. J.; Vruchte, D. T.; Neville, David C. A.; Platt, Frances M.; van Blitterswijk, Wim J. (Article)
      • Accurate whole human genome sequencing using reversible terminator chemistry 

        Bentley, David R.; Lee, Sarah E. (Article)
      • ACE inhibitors: use, actions and prescribing rationale. 

        Waterfield, Jon (Article)
      • Actinometric and Φ-order photodegradation properties of anti-cancer Sunitinib. 

        Maafi, Mounir; Lee, Lok Yan (Article)
        The photodegradation reaction of Sunitinib (SUT), occurring via Z–E photoisomerization, has been evaluated in this study using the recently developed –order kinetics. In ethanol, the forward (Z E) photoreaction of SUT was ...
      • Activity and mechanism of action of selected biocidal agents on Gram-positive and –negative bacteria. 

        Walsh, Susannah E.; Maillard, J-Y.; Russell, A. D.; Catrenich, C. E.; Charbonneau, D. L.; Bartolo, R. G. (Article)
      • Activity of Antioxidants from Crocus sativus L. Petals: Potential Preventive Effects towards Cardiovascular System 

        Zeka, Keti; Marrazzo, Pasquale; Micucci, Matteo; Ruparelia, Ketan C.; Arroo, Randolph R.J.; Macchiarelli, Guido; Nottola, Stefania Annarita; Continenza, Maria Adelaide; Chiarini, Alberto; Angeloni, Cristina; Hrelia, Silvana; Budriesi, Roberta (Article)
        The petals of the saffron crocus (Crocus sativus L.) are considered a waste material in saffron production, but may be a sustainable source of natural biologically active substances of nutraceutical interest. The aim of ...
      • Activity of DNA-targeted C8-linked pyrrolobenzodiazepine(PBD)-heterocyclic polyamide conjugates against aerobically and hypoxically grown Mycobacterium tuberculosis under acidic and neutral conditions 

        Iacobino, Angelo; Giannoni, Federico; Fattorini, Lanfranco; Brucoli, F. (Article)
        Mycobacterium tuberculosis (Mtb) is the aetiological agent of tuberculosis, the leading cause of death worldwide from a single infectious agent. Mtb is a highly-adaptable human pathogen that might enter a dormant non-replicating ...
      • The acute and long-term neurotoxic effects of MDMA on marble burying behaviour in mice. 

        Saadat, K. S.; Elliott, J. M.; Colado, M. I.; Green, A. R. (Article)
      • Acute onset by 5-HT6 receptor activation on rat brain brain-derived neurotrophic factor and activity-regulated cytoskeletal-associated protein mRNA expression. 

        Zetterstrom, T. S. C.; de Foubert, G.; O'Neill, M. J. (Article)
      • Ad libitum administration of sucrose during adolescence causes changes in dopamine neurotransmission which are partially reversed by glucagon-like peptide 

        Omoloye, Adesina; Gronier, Ben (Conference)
        Ad libitum administration of sucrose during adolescence causes changes in dopamine neurotransmission which are partially reversed by glucagon-like peptide. Background: Overconsumption of sugar in children, associated with ...
      • Addressing the Employability Needs of Forensic Science Graduates 

        Fowler, Mark R.; Brawn, R. J.; Marriott, Anna; Roy, P. Lucy; Scott, Nigel W.; Patterson, H. B. (Conference)
      • Adherence to cardiovascular pharmacotherapy assessed by quantitative LC-HRMS analysis of dried blood spots 

        Tanna, Sangeeta; Bernieh, Dennis; Lawson, Graham (Conference)
        Up to ~50% of patients prescribed cardiovascular (CVD) drugs do not adhere to their prescribed regimen. Non-adherence impacts on patient health and healthcare system costs. Dried blood spot (DBS) sampling was used to collect ...

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