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Now showing items 1-20 of 791

1H NMR investigations of the molecular nature of cobalt (II) ions in human saliva

Chang, H. ; Tomoda, S. ; Silwood, C. ; Lynch, E. ; Grootveld, M. (Article)

High-resolution 1H NMR spectroscopy demonstrated that addition of Co(II) ions to isolated human salivary supernatants (HSSs) gave rise to its complexation by a variety of biomolecules. The relative efficacies of these ...
1H NMR-based metabolomics reveals neurochemical alterations in the brain of adolescent rats following acute methylphenidate administration

Quansah, Emmanuel ; Ruiz-Rodado, Victor ; Grootveld, M. ; Probert, Fay ; Zetterstrom, T. S. C. (Article)

The psychostimulant methylphenidate (MPH) is increasingly used in the treatment of attention deficit hyperactivity disorder (ADHD). While there is little evidence for common brain pathology in ADHD, some studies suggest a ...
1H NMR-Linked Metabolomics Analysis of Liver from a Mouse Model of NP-C1 Disease

Ruiz-Rodado, Victor ; Nicoli, Elena-Raluca ; Probert, Fay ; Smith, David A. ; Morris, Lauren ; Wassif, Christopher A. ; Platt, Frances M. ; Grootveld, M. (Article)
1H NMR-Linked Urinary Metabolic Profiling of Niemann-Pick Class C1 (NPC1) Disease: Identification of Potential New Biomarkers using Correlated Component Regression (CCR) and Genetic Algorithm (GA) Analysis Strategies

Ruiz-Rodado, V. ; Luque-Baena, R. M. ; te Vruchte, D. J. ; Probert, Fay ; Lachmann, R. H. ; Hendriksz, Christian J. ; Wraith, James E. ; Imrie, Jackie ; Elizondo, David ; Sillence, Daniel J. ; Clayton, P. ; Platt, Frances M. ; Grootveld, M. (Article)

Niemann-Pick Class 1 (NPC1) disease is a rare, debilitating neurodegenerative lysosomal storage disease; however, urinary biomarkers available for it and its prognosis are currently limited. In order to identify and establish ...
Accumulation of glycosphingolipids in Niemann-Pick C disease disrupts endosomal transport.

Sillence, Daniel J. ; Lloyd-Evans, E. ; Veldman, R. J. ; Vruchte, D. T. ; Neville, David C. A. ; Platt, Frances M. ; van Blitterswijk, Wim J. (Article)
Accurate whole human genome sequencing using reversible terminator chemistry

Bentley, David R. ; Lee, Sarah E. (Article)
ACE inhibitors: use, actions and prescribing rationale.

Waterfield, Jon (Article)
Actinometric and Φ-order photodegradation properties of anti-cancer Sunitinib.

Maafi, Mounir ; Lee, Lok Yan (Article)

The photodegradation reaction of Sunitinib (SUT), occurring via Z–E photoisomerization, has been evaluated in this study using the recently developed –order kinetics. In ethanol, the forward (Z E) photoreaction of SUT was ...
Activity and mechanism of action of selected biocidal agents on Gram-positive and –negative bacteria.

Walsh, Susannah E. ; Maillard, J-Y. ; Russell, A. D. ; Catrenich, C. E. ; Charbonneau, D. L. ; Bartolo, R. G. (Article)
The acute and long-term neurotoxic effects of MDMA on marble burying behaviour in mice.

Saadat, K. S. ; Elliott, J. M. ; Colado, M. I. ; Green, A. R. (Article)
Acute onset by 5-HT6 receptor activation on rat brain brain-derived neurotrophic factor and activity-regulated cytoskeletal-associated protein mRNA expression.

Zetterstrom, T. S. C. ; de Foubert, G. ; O'Neill, M. J. (Article)
Addressing the Employability Needs of Forensic Science Graduates

Fowler, Mark R. ; Brawn, R. J. ; Marriott, Anna ; Roy, P. Lucy ; Scott, Nigel W. ; Patterson, H. B. (Conference)
Adherence to cardiovascular pharmacotherapy assessed by quantitative LC-HRMS analysis of dried blood spots

Tanna, Sangeeta ; Bernieh, Dennis ; Lawson, Graham (Conference)

Up to ~50% of patients prescribed cardiovascular (CVD) drugs do not adhere to their prescribed regimen. Non-adherence impacts on patient health and healthcare system costs. Dried blood spot (DBS) sampling was used to collect ...
Adherence to medication assessed using dried blood spot analysis

Tanna, Sangeeta ; Lawson, Graham (Article)
ADP stimulation of inositol phosphates in hepatocytes: Role of conversion to ATP and stimulation of P2Y2 receptors.

Dixon, C. J. ; Hall, J. F. ; Boarder, M. R. (Article)
Advanced Nanoparticles in Medical Biosensors

Li, Songjun ; Fei, Dan ; Cimorra,Christian ; Ge, Yi (Book chapter)
AFM visualization of sub-50nm polyplex disposition to the nuclear pore complex without compromising the integrity of the nuclear envelope

Andersen, Helene ; Parhamifar, Laden ; Hunter, Alan Christy ; Shahin, Victor ; Moghimi, S. M. (Article)

It has been questioned as to whether polyplexes in the cytoplasm can reach the nuclear compartment and if so in what form. By applying atomic force microscopy (AFM) to the nuclear envelope and the nuclear pore complexes, ...
Age-dependent effects of methylphenidate in the prefrontal cortex: Evidence from electrophysiological and Arc gene expression measurements.

Gronier, Ben ; Aston, James ; Liauzun, Claire ; Zetterstrom, T. S. C. (Article)
Age-related attitude to malaria and travel

Goodyer, Larry (Article)
Aggregation and caking processes of granular materials: continuum model and simulation with application to sugar.

Christakis, N. ; Wang, J. (Jihong) ; Patel, M. K. ; Bradley, M. S. A. ; Leaper, Mark C. ; Cross, M. (Article)

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