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    • Browsing Leicester School of Pharmacy by Subject
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    Browsing Leicester School of Pharmacy by Subject "XIAP BIR3"

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      • Solid phase synthesis of Smac/DIABLO-derived peptides using a ‘Safety-Catch’ resin: Identification of potent XIAP BIR3 antagonists 

        Elsawy, M.; Martin, L.; Tikhonova, I.; Walker, B. (Article)
        The N-terminal sequence of the Smac/DIABLO protein is known to be involved in binding to the BIR3 domain of the anti-apoptotic proteins IAPs, antagonizing their action. Short peptides and peptide mimetics based on the first ...

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