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Browsing Leicester School of Pharmacy by Publication Date
Now showing items 1-20 of 935
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(Article)
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(Article)The general approach to globular proteins dynamical structure investigation by NMR and time domain dielectric spectroscopy (TDDS) is presented. The information on macromolecular dynamical behavior in the case of these two ...
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(Article)The hardware and software designs for fast measurement of dielectric properties of different substances over a wide range of characteristic times (10−5–10−10 s) by means of time domain dielectric spectroscopy (TDS) are ...
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(Article)The effects of lithium (Li+) on the adenylyl cyclase and inositol phospholipid receptor signalling pathways were compared directly in noradrenergic and carbachol stimulated rat brain cortical tissue slices. Li+ was a ...
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(Article)In an inositol-depleted 1321 N1 astrocytoma cell line, propranolol at 0.5 mM concentration and carbachol in the presence of Li+ induce a large increase (30-60-fold) in the amount of CMP-phosphatidate, the lipid substrate ...
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(Article)In order to address the issue of how inositol phospholipid synthesis is controlled in a resting cell we looked for enhanced [3H]phosphatidylinositol (PtdIns) labelling in response to the hydrolysis of cell surface PtdIns. ...
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(Article)Non-selective NMR relaxation of protein and water protons at various resonance frequencies as well as Time Domain Dielectric Spectroscopy (TDDS) were applied to study the molecular motions in lysozyme and myoglobin solutions. ...
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(Article)The results of dynamic protein behavior in solution studied by time domain dielectric spectroscopy (TDDS) are presented. The analyses for myoglobin solutions at concentrations 50, 120 and 150 mg/ml in the temperature ...
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(Conference)
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(Article)The localization of phorbol ester-sensitive phospholipase D (PLD) in baby hamster kidney cells has been investigated by determining the subcellular distribution of the phosphatidylbutanol produced when the cells are incubated ...
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(Article)The new time domain measurement system for dielectric measurements is described. The current model is comprised of an IBM PC-AT/486, ‘‘TDM-2,’’ a new time domain measurement system, a set of thermostabilized sample holders, ...
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(Article)The subcellular distributions of the enzymes which synthesise sphingomyelin (SM) and glucosylceramide (GluCer) from ceramide have been assessed in BHK cells. On a sucrose density gradient GluCer synthase (a marker of the ...
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(Article)We have investigated whether the increases in ceramide levels that occur during apoptosis in SKW 6.4 cells induced by anti-Fas antibody depend on the activation of caspases. Using cells prelabelled to equilibrium with ...
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(Article)The results of the investigation of protein molecule dynamic in solution by Time Domain Dielectric Spectroscopy are presented. The horse myoglobin solutions in wide range of concentration from 0.6% to 54% at 20°C have been ...
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(Article)After the degradation of cell-surface sphingomyelin (SM) by exogenous sphingomyelinase (SMase), the resynthesis of SM by baby-hamster kidney (BHK) and human leukaemia-60 (HL-60) cells was examined in relation to utilization ...
Now showing items 1-20 of 935
