Browsing Leicester School of Pharmacy by Author "Lawson, Graham"
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Adherence to cardiovascular pharmacotherapy assessed by quantitative LC-HRMS analysis of dried blood spots
Tanna, Sangeeta; Bernieh, Dennis; Lawson, Graham (Conference)Up to ~50% of patients prescribed cardiovascular (CVD) drugs do not adhere to their prescribed regimen. Non-adherence impacts on patient health and healthcare system costs. Dried blood spot (DBS) sampling was used to collect ... -
Analytical Chemistry for Assessing Medication Adherence
Tanna, Sangeeta; Lawson, Graham (Book)The lack of adherence to medication is a growing public health problem worldwide and is costing many patients their chance to return to good health and healthcare systems billions of dollars. Analytical Chemistry for ... -
Analytical methods used in conjunction with dried blood spots.
Tanna, Sangeeta; Lawson, Graham (Article)Review of different analytical methods used to obtain medically related data from dried blood spots. Advantages and limitations of the methodologies are discussed. -
ATR-FTIR for rapid detection and quantification of counterfeit medicines
Ogwu, John; Lawson, Graham; Tanna, Sangeeta (Conference)From therapeutic to lifestyle medicines, the counterfeiting of medicines has been on the rise in recent times [1]. Estimates indicate that about 10% of medicines worldwide are counterfeits with much higher figures in ... -
Can quantitative dried blood spot analyses be an aid to medicine optimization in cardiovascular diseases?
Bernieh, Dennis; Lawson, Graham; Tanna, Sangeeta (Conference)Introduction: Over 355 million prescriptions were dispensed for cardiovascular diseases in the UK in 2013 [1]. Half of these, costing the NHS £2.3 billion, were wasted because patients do not take their medicines as ... -
Captopril Determination in Dried Blood Spot Samples with LC-MS and LCHRMS: A Potential Method for Neonate Pharmacokinetic Studies
Lawson, Graham; Mulla, Hussain; Tanna, Sangeeta (Article)The use of blood spot collection cards was investigated as a means of obtaining small volume samples for the analysis of therapeutic drugs for the purpose of neonatal pharmacokinetic studies. We describe the development ... -
Cardiovascular Drug Medication Adherence Assessed by Dried Blood Spot Analysis
Tanna, Sangeeta; Lawson, Graham (Article)The use of dried blood spot (DBS) collection cards was investigated for the detection of therapeutic drugs used in cardiovascular therapy for assessing medication adherence. A liquid chromatography-high resolution mass ... -
Cardiovascular drug monitoring using quantitative LC-HRMS analysis of self-collected micro-volume blood samples
Tanna, Sangeeta; Bernieh, Dennis; Alalaqi, Ahmed; Lawson, Graham (Conference)Background Evidence suggests that ˃50% of cardiovascular (CVD) disease patients do not adhere to treatment thus impacting on patient health, additional healthcare costs and medicines wastage. DBS microsampling combined ... -
Comparison of VAMS and card based microsampling with LC-HRMS analysis to assess cardiovascular drug levels
Bernieh, Dennis; Lawson, Graham; Tanna, Sangeeta (Conference)Summary: An objective means of assessing medication adherence is needed to enable patients get the maximum therapeutic benefits from their medication. A bioanalytical assay using dried blood spot (DBS) and volumetric ... -
Counterfeit or just poor quality?
Armitage, Rachel; Lawson, Graham; Tanna, Sangeeta (Conference)Counterfeit medicines are a major public health issue. The World Health Organisation suggests that the occurrence of counterfeits range from 1% in high income countries to as much as ~30-40% in low to middle income countries, ...