Browsing Leicester School of Pharmacy by Title
Now showing items 949-968 of 1197
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Racemisation of N-Fmoc phenylglycine under mild microwave-SPPS and conventional stepwise SPPS conditions: attempts to develop strategies for overcoming this
(Article)We have been engaged in the microwave-solid phase peptide synthesis (SPPS) synthesis of the phenylglycine (Phg)-containing pentapeptide H-Ala-Val-Pro-Phg-Tyr-NH2 (1) previously demonstrated to bind to the so-called BIR3 ... -
Radiostability of florfenicol in the solid state
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Randomized trial of red cell washing for the prevention of transfusion-associated organ injury in cardiac surgery.
(Article)BACKGROUND: Experimental studies suggest that mechanical cell washing to remove pro-inflammatory components that accumulate in the supernatant of stored donor red blood cells (RBCs) might reduce inflammation and organ ... -
Rapid instrumental detection and quantification of counterfeit pharmaceutical tablet formulations
(Conference)From therapeutic to lifestyle medicines, the counterfeiting of medicines has been on the rise in recent times. Estimates indicate that about 10% of medicines worldwide are counterfeits with much higher figures in developing ... -
Rational design, synthesis and preliminary biological evaluation of novel C8-linked pyrrolobenzodiazepine-5′-O-[N-(salicyl)sulfamoyl]adenosine conjugates (PBD-Sal-AMS) as anti-tubercular probes with dual mode of action.
(Conference)Tuberculosis (TB), a disease caused by Mycobacterium tuberculosis, affects an estimated 10 million people worldwide, causing around 2 million human deaths yearly. The emergence of multi-drug resistant strains and lack of ... -
Rationale of using Vinca minor Linne dry extract phytocomplex as a vincamine’s oral bioavailability enhancer
(Article)Vincamine is a poorly soluble potent neuroprotector and cerebral vasodilator, used for the treatment for CNS disorders. In some cases, the bioavailability of pure compounds is strongly influenced by the co-administration ... -
Reactive Oxygen: a novel antimicrobial mechanism for targeting biofilm-associated infection
(Article)Reactive oxygen species (ROS) is a novel therapeutic strategy for topical or local application to wounds, mucosa or internal structures where there may be heavy bacterial bioburden with biofilm and chronic inflammation. ... -
Real-time monitoring of the mechanism of ibuprofen-cationic dextran crystanule formation using crystallization process informatics system (CryPRINS)
(Article)One step aqueous melt-crystallization and in situ granulation was utilized to produce ibuprofen-cationic dextran [diethylaminoethyl dextran (Ddex)] conjugate crystanules without the use of surfactants or organic solvents. ... -
Recent Advances in Avian Egg Science: A Review
(Article)Eggs and egg products form an integral part of the food chain. As such, research into egg structure, function, and production has made an important contribution to the field of poultry science. The past decade has seen ... -
Recent advances in chemistry, therapeutic properties and sources of polydatin
(Article)Polydatin (PLD), the 3-O-β-glucopyranoside of the well-known stilbenoid compound resveratrol, is a major compound of Fallopia japonica (Houtt.) R. Decr. (Japanese knotweed), which is widely used in traditional Chinese ... -
Recent advances in exosome-based nanovehicles as RNA interference therapeutic carriers
(Article)RNA interference (RNAi) therapeutics (siRNA, miRNA, etc.) represent an emerging medicinal remedy for a variety of ailments. However, their low serum stability and low cellular uptake signi cantly restrict their clinical ... -
Recommended antimicrobial therapy for common inpatient infections: a comparative review of guidelines across 51 hospital trusts in England
(Article)Background The number of different antimicrobial recommendations between hospital trusts for the same indication in England is unknown. Aim We aimed to evaluate the heterogeneity of antimicrobial recommendations for ...