Browsing Leicester School of Pharmacy by Title
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Lactobacillus rhamnosus GG conditioned media modulates acute reactive oxygen species and nitric oxide in J774 murine macrophages.
(Article)Phagocytes such as macrophages are capable of detecting and killing pathogenic bacteria by producing reactive oxygen and nitrogen species. Formation of free radicals in macrophages may be regulated by probiotics or by ... -
Laundering of Healthcare Uniforms
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LC-HRMS analysis of 133 patient micro-volume blood samples to allow clinical assessment of medication adherence
(Conference)133 DBS card/VAMS micro-volume blood samples were analysed by LC-HRMS to determine if therapeutic levels of the prescribed cardiovascular (CVD) drugs were present. This research focussed on the top 11 UK prescribed CVD ... -
LC-HRMS analysis of dried blood spot samples for assessing adherence to cardiovascular medications
(Article)Research suggests that ~60% of patients prescribed cardiovascular drugs do not take their medication correctly. The analysis of dried blood spot samples (DBS) by liquid chromatography-high resolution mass spectrometry ... -
Leather Surfaces: Species Differentiation and Fingermark Visualisation
(Conference)The predominance of latent fingermarks at crime scenes highlights the paramount importance of methodologies for their development and visualisation. However, despite the array of available techniques, prior exposure to ... -
Lipid–Protein Interactions in Niemann–Pick Type C Disease: Insights from Molecular Modeling
(Article)The accumulation of lipids in the late endosomes and lysosomes of Niemann–Pick type C disease (NPCD) cells is a consequence of the dysfunction of one protein (usually NPC1) but induces dysfunction in many proteins. We used ... -
Liquid chromatography-high resolution mass spectrometry applied to therapeutic drug monitoring using DBS sampling
(Conference)Introduction: Quantitative dried blood spot (DBS) analysis was used to investigate if the accurate mass capability (±2ppm m/z) of high resolution mass spectrometry (HRMS) would provide compound specificity comparable to ... -
Lithium treatment of affective disorders; effects on the cyclic AMP and inositol phospholipid signalling pathways’
(Article)The effects of lithium (Li+) on the adenylyl cyclase and inositol phospholipid receptor signalling pathways were compared directly in noradrenergic and carbachol stimulated rat brain cortical tissue slices. Li+ was a ... -
Long term stability and storage of acrylic derivatised glucose responsive dextran-concanavalin A gels
(Conference)The long term stability of photopolymerised acrylic derivatives of dextran and concanavalin A (con A) and dextran and con A mixtures has been shown at 20 and 37°C by rheological characterisation when stored with and without ... -
Long term stability of glucose responsive dextran methacylate-concanavalin A Methacrylamide gels as part of an implantable artificial pancreas
(Article)A closed loop implantable insulin delivery device which delivers insulin to the peritoneum in an automated fashion linked to changing glucose levels has been developed and previously tested in diabetic rats and pigs. The ... -
Loss of PINK1 enhances neurodegeneration in a mouse model of Parkinson's disease triggered by mitochondrial stress.
(Article)Parkinson's disease (PD) shows a complex etiology, where both genetic and environmental factors contribute to initiation and advance of pathology. Mitochondrial dysfunction and mutation of genes implicated in mitochondria ... -
Low concentrations of nitric oxide modulate Streptococcus pneumoniae biofilm metabolism and antibiotic tolerance
(Article)Streptococcus pneumoniae is one of the key pathogens responsible for otitis media (OM), the most common infection in children and the largest cause of childhood antibiotic prescription. Novel therapeutic strategies that ... -
Low-Dose Nitric Oxide as Targeted Anti-biofilm Adjunctive Therapy to Treat Chronic Pseudomonas aeruginosa Infection in Cystic Fibrosis
(Article)Despite aggressive antibiotic therapy, bronchopulmonary colonization by Pseudomonas aeruginosa causes persistent morbidity and mortality in cystic fibrosis (CF). Chronic P. aeruginosa infection in the CF lung is associated ... -
Low-Field, Benchtop NMR Spectroscopy as a Potential Tool for Point-of-Care Diagnostics of Metabolic Conditions: Validation, Protocols and Computational Models
(Article)Novel sensing technologies for liquid biopsies offer promising prospects for the early detection of metabolic conditions through omics techniques. Indeed, high-field nuclear magnetic resonance (NMR) facilities are routinely ...