Browsing Leicester School of Pharmacy by Title
Now showing items 255-274 of 1194
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D-methionine interferes with non-typeable Haemophilus influenzae peptidoglycan synthesis during growth and biofilm formation
(Article)Non-typeable Haemophilus influenzae (NTHi) is an opportunistic pathogen that plays a major role in a number of respiratory tract infections, including otitis media, cystic fibrosis and chronic obstructive pulmonary disease. ... -
Dehydration without Heating: Use of Polymer-Assisted Grinding for Understanding the Stability of Hydrates in the Presence of Polymeric Excipients
(Article)Hydrates are ubiquitous multicomponent solids of particular interest in the pharmaceutical field. As such, there is a practical need of monitoring the stability of this class of solids, especially when formulated with ... -
Design, synthesis, antitumor activity and molecular docking study of novel 5-deazaalloxazine analogs
(Article)Protein tyrosine kinases (PTKs) are the most potential therapeutic targets for cancer. Herein, we present a sound rationale for synthesis of a series of novel 2-(methylthio), 2-(substituted alkylamino), 2-(heterocyclic ... -
Designer fibers from 2D to 3D – Simultaneous and controlled engineering of morphology, shape and size
(Article)Topography and surface morphology of micrometer and nanometer scaled fibrous biomaterials are crucial for bioactive component encapsulation, release, promoting cell proliferation and interaction within biological environment. ... -
Designing Peptide/Graphene Hybrid Hydrogels through Fine-Tuning of Molecular Interactions
(Article)A recent strategy that has emerged for the design of increasingly functional hydrogels is the incorporation of nanofillers in order to exploit their specific properties to either modify the performance of the hydrogel or ... -
Detection and Determination of Methanol and Further Potential Toxins in Human Saliva Collected from Cigarette Smokers: A 1H NMR Investigation
(Article)Introduction/Objectives: The deleterious health effects of tobacco smoking are now widely recognized and documented. High-resolution 1 H NMR analysis of human saliva provides a high level of valuable molecular information ... -
Detection of drugs of abuse and pharmaceuticals in drinking water
(Conference)The focus of this study is to develop a suitable extraction and analytical method for the detection of drugs of abuse and pharmaceuticals in drinking water. This is in response to concerns that traditional and current water ... -
The detection of drugs of abuse and pharmaceuticals in drinking water using solid-phase extraction and liquid chromatography-mass spectrometry
(Article)Pharmaceuticals and drugs of abuse including novel psychoactive substances (NPS) are emerging as newer contaminants in the aquatic environment. The presence of such pollutants has implications on the environment as well ... -
Detection of Drugs of Abuse in Waste Water
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Detection of multiple steroidal compounds in synthetic urine using comprehensive gas chromatography-mass spectrometry (GC×GC-MS) combined with a molecularly imprinted polymer clean-up protocol
(Article)method capable of screening for multiple steroids in urine has been developed, using a series of twelve structurally similar, and commercially relevant compounds as target analytes. A molecularly imprinted solid phase ... -
Determination of Dacarbazine Φ‐Order Photokinetics, Quantum Yields, and Potential for Actinometry.
(Article)The characterization of drugs’ Photodegradation kinetics is more accurately achieved by means of the recently developed –order kinetics than by the 0th–, 1st– and/or 2nd–order classical treatments. The photodegradation ... -
Determination of Heavy Metals Present in the Hypoglycemic Karela Powder: An Analytical Assay
(Article)Diabetes is a common health condition associated with heightened glucose content in the blood due to impaired insulin production/function. Considering current societal trends, the number of patients with this condition is ...