• Development and Validation of an In‐Line API Quantification Method Using AQbD Principles Based on UV‐Vis Spectroscopy to Monitor and Optimise Continuous Hot Melt Extrusion Process 

  Almeida, Juan; Bezerra, Mariana; Markl, Daniel; Berghaus, Andreas; Borman, Phil; Schlindwein, W. S. (Article)

  A key principle of developing a new medicine is that quality should be built in, with a thorough understanding of the product and the manufacturing process supported by appropriate process controls. Quality by design ...

• The role of protective clothing in healthcare and its 
decontamination 

  Laird, Katie; Owen, Lucy (Book chapter)

  Healthcare-associated infections (HAIs) are a significant cause of morbidity and mortality and pose a major economic burden. Infection control is therefore important in healthcare environments to minimize the transmission ...

• Advanced hydrogels for treatment of diabetes 

  Reyes-Martínez, J.; Ruiz-Pacheco, J.; Vallejo-Cardona, A.; Flores-Valdez, M.; Castillo-Diaz, L.; Elsawy, M. (Article)

  Diabetes mellitus is a chronic disease characterized by high levels of glucose in the blood, which leads to metabolic disorders with severe consequences. Today, there is no cure for diabetes. The current management for ...

• Generation of High-Affinity Molecularly Imprinted Nanoparticles for Protein Recognition via a Solid-Phase Synthesis Protocol 

  Canfarotta, Francesco; Piletsky, Sergey; Turner, Nicholas (Book chapter)

  Molecularly imprinted polymers are leading technology in the development of protein biomimetics. This chapter describes the protocol for the synthesis of protein imprinted nanoparticles. These materials exhibit exceptional ...

• Microencapsulation for Improved Mosquitoes Repellent Efficacy of Cotton Fabrics 

  Grancaric, A. M.; Laird, Katie; Botteri, L; Shen, Jinsong; Laatikainen, K (Conference)

  In recent years, mosquitoes that can transfer viruses causing vector-borne diseases, such as dengue fever, chikungunya, Zika and West Nile virus have dramatically increased and reached Europe. In 2018 a higher number of ...

• Hyphenated mass spectrometry techniques for assessing medication adherence: advantages, challenges, clinical applications and future perspectives 

  Tanna, Sangeeta; Ogwu, John; Lawson, Graham (Article)

  Nonadherence to prescribed pharmacotherapy is an understated public health problem globally and is costing many patients their chance to return to good health and healthcare systems billions. Clinicians need an accurate ...

• A Germ’s Journey- African Edition 

  Laird, Katie; Crosby, Sapphire; Younie, Sarah (Book)

• Gene expression analysis of transport channels in Enterococcus faecium (VRE) 

  Al hareth, Zakia; Owen, L.; Dixon, C. J.; Smith, L. M.; Laird, Katie (Conference)

  Introduction: An important aspect of the bacterial response towards stress and environmental stimuli is alteration of gene expression levels . A combination of carvacrol, cuminaldehyde, and vancomycin has previously been ...

• Racemisation of N-Fmoc phenylglycine under mild microwave-SPPS and conventional stepwise SPPS conditions: attempts to develop strategies for overcoming this 

  Elsawy, M.; Hewage, C.; Walker, B. (Article)

  We have been engaged in the microwave-solid phase peptide synthesis (SPPS) synthesis of the phenylglycine (Phg)-containing pentapeptide H-Ala-Val-Pro-Phg-Tyr-NH2 (1) previously demonstrated to bind to the so-called BIR3 ...

• Smac-derived aza-peptide as an aminopeptidase-resistant XIAP BIR3 antagonist 

  Elsawy, M.; Martin, L.; Tikhonova, I.; Walker, B. (Article)

  The peptidic nature of anti-IAPs N-terminus Smac-derived peptides precludes their utilization as potential therapeutic anticancer agents. Recent advances in the development of novel Smacderived peptidomimetics and non-peptidic ...

• Solid phase synthesis of Smac/DIABLO-derived peptides using a ‘Safety-Catch’ resin: Identification of potent XIAP BIR3 antagonists 

  Elsawy, M.; Martin, L.; Tikhonova, I.; Walker, B. (Article)

  The N-terminal sequence of the Smac/DIABLO protein is known to be involved in binding to the BIR3 domain of the anti-apoptotic proteins IAPs, antagonizing their action. Short peptides and peptide mimetics based on the first ...

• In vivo characterisation of a therapeutically relevant self-assembling 18F- labelled β-sheet forming peptide and its hydrogel using positron emission tomography 

  Morris, O.; Elsawy, M.; Fairclough, M.; Williams, K.; McMahon, A.; Grigg, J.; Forster, D.; Miller, A.; Saiani, A.; Prenant, C. (Article)

  Positron emission tomography (PET) and fluorescence labelling have been used to assess the pharmacokinetics, biodistribution and eventual fate of a hydrogel‐forming nonapeptide, FEFKFEFKK (F9), in healthy mice, using ...

• Osteogenic differentiation of human mesenchymal stem cells promotes mineralization within a biodegradable peptide hydrogel 

  Castillo-Díaz, L.; Elsawy, M.; Saiani, A.; Gough, J.; Miller, A. (Article)

  An attractive strategy for the regeneration of tissues has been the use of extracellular matrix analogous biomaterials. Peptide-based fibrillar hydrogels have been shown to mimic the structure of extracellular matrix ...

• RNA extraction from self-assembling peptide hydrogels to allow qPCR analysis 

  Burgess, K.; Workman, V.; Elsawy, M.; Miller, A.; Oceandy, D.; Saiani, A. (Article)

  Self-assembling peptide hydrogels offer a novel 3-dimensional platform for many applications in cell culture and tissue engineering but are not compatible with current methods of RNA isolation; owing to interactions between ...

• Controlling Self-Assembling Peptide Hydrogel Properties through Network Topology 

  Gao, J.; Tang, C.; Elsawy, M.; Smith, A.; Miller, A.; Saiani, A. (Article)

  Self-assembling peptide-based hydrogels have encountered increasing interest in the recent years as scaffolds for 3D cell culture or for controlled drug delivery. One of the main challenges is the fine control of the ...

• Modification of β-Sheet Forming Peptide Hydrophobic Face: Effect on Self-Assembly and Gelation 

  Elsawy, M.; Smith, A.; Hodson, N.; Squires, A.; Miller, A.; Saiani, A. (Article)

  β-Sheet forming peptides have attracted significant interest for the design of hydrogels for biomedical applications. One of the main challenges is the control and understanding of the correlations between peptide molecular ...

• Anisotropic pH-Responsive Hydrogels Containing Soft or Hard Rod-Like Particles Assembled Using Low Shear 

  Milani, A.; Fielding, L.; Greensmith, P.; Adlam, D.; Freemont, A.; Hoyland, J.; Hidson, N.; Elsawy, M.; Miller, A.; Ratcliffe, L.; Mykhaylyk, O.; Armes, S.; Saunders, B. (Article)

  A simple and versatile low-shear approach for assembling hydrogels containing aligned rod-like particles (RLPs) that are birefringent and exhibit pH-triggered anisotropic swelling is developed. Anisotropic composite hydrogels ...

• Designing Peptide/Graphene Hybrid Hydrogels through Fine-Tuning of Molecular Interactions 

  Wychowaniec, J.; Iliut, M.; Zhou, M.; Moffat, J.; Elsawy, M.; Pinheiro, W.; Hoyland, J.; Miller, A.; Vijayaraghavan, A.; Saiani, A. (Article)

  A recent strategy that has emerged for the design of increasingly functional hydrogels is the incorporation of nanofillers in order to exploit their specific properties to either modify the performance of the hydrogel or ...

• Dual-Function Antimicrobial Laundry Supplement and Textile Coating for the Decontamination of Healthcare Laundry 

  Owen, Lucy; Laird, Katie (Conference)

  Background: In the UK nurses’ uniforms are domestically laundered, posing a threat of cross contamination of healthcare-associated infections. The UK Department of Health recommends washing uniforms at 60ºC, however nurses ...

• From formulation to in vivo model: A comprehensive study of a synergistic relationship between vancomycin, carvacrol and cuminaldehyde against Enterococcus faecium 

  Owen, Lucy; Webb, Joseph P.; Green, Jeffrey; Smith, Laura J.; Laird, Katie (Article)

  Vancomycin Resistant Enterococcus faecium (VRE) has become endemic in healthcare settings, reducing treatment options for enterococcal infections. New antimicrobials for VRE infections are a high priority, but the development ...

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