• Recent advances in exosome-based nanovehicles as RNA interference therapeutic carriers 

  Maheshwari, Rahul ; Tekade, Muktika ; Gondaliya, Piyush ; Kalia, Kiran ; D’Emanuele, Antony ; Tekade, Rakesh Kumar (Article)

  RNA interference (RNAi) therapeutics (siRNA, miRNA, etc.) represent an emerging medicinal remedy for a variety of ailments. However, their low serum stability and low cellular uptake signi cantly restrict their clinical ...
• Engineering and development of chitosan-based Nanocoatings for Ocular Contact Lenses 

  Mehta, P. ; Al-Kinani, Ali A. ; Arshad, Muhammad Sohail ; Singh, Neenu ; van der Merwe, Susanna M. ; Chang, Ming-Wei ; Alany, Raid G. ; Ahmad, Z. (Article)

  The research manuscript reports on Electrohydrodynamic Atomisation (EHDA) to engineer on-demand novel coatings for ocular contact lenses. A formulation approach was adopted to modulate the release of timolol maleate (TM) ...
• Φ-order spectrophotokinetic characterisation and quantification of trans-cis oxyresveratrol reactivity, photodegradation and actinometry. 

  Maafi, Mounir ; Alqarni, M. (Article)

  A new Φ-order kinetic method was proposed in this study for the investigation of trans-cis photoisomerization reaction of Oxyresveratol (ORVT) subjected to non-isosbestic irradiation. In ethanolic media, it has been proven ...
• Quinazoline derivatives as selective CYP1B1 inhibitors 

  Siddique, Mohd Usman Mohd ; McCann, Glen J. P. ; Sonawane, Vinay ; Horley, Neill ; Gatchie, Linda ; Joshi, Prashant ; Bharate, Sandip B. ; Jayaprakash,Venkatesan ; Sinha, Barij N. ; Chaudhuri, B. (Article)

  CYP1B1 is implicated to have a role in the development of breast, ovarian, renal, skin and lung carcinomas. It has been suggested that identification of potent and specific CYP1B1 inhibitors can lead to a novel treatment ...
• Pharmaceutical excipients properties and screw feeder performance in continuous processing lines: a Quality by Design (QbD) approach 

  Santos, B. ; Carmo, F. ; Schlindwein, W. S. ; Muirhead, G. ; Rodriguez, C. ; Cabral, L. ; Westrup, J. ; Pitt, K. (Article)

  Screw feeder performance is a critical aspect in continuous manufacturing processes. Pharmaceutical excipients, such as mannitol, microcrystalline cellulose, lactose monohydrate, and anhydrous dibasic calcium phosphate can ...
• Solubility and dissolution rate enhancement of ibuprofen by co-milling with polymeric excipients 

  Smith, Geoff ; Pedge, Nicholas ; Khan, Karrar A ; Bukhari, Nadeem Irfan ; Hussain, Amjad ; Ermolina, I. (Article)

  The aim of this study was to enhance the kinetic solubility and dissolution rate of ibuprofen by co-milling with different excipients and to establish the underlying mechanism(s) for such enhancement. In the first-part, ...
• Montelukast photodegradation: Elucidation of Ф-order kinetics, determination of quantum yields and application to actinometry. 

  Maafi, W. ; Maafi, Mounir (Article)

  A recently developed F–order semi–emperical integrated rate–law for photoreversible AB(2F) photoreversible reactions has been successfully applied to investigate Montelukast sodium (Monte) photodegradation kinetics in ...
• Correlation between molecular dynamics and physical stability of two milled anhydrous sugars: lactose and sucrose 

  Smith, Geoff ; Hussain, Amjad ; Bukhari, Nadeem Irfan ; Ermolina, I. (Article)

  The process of milling often results in amorphization and the physical stability of amorphous phase is linked with its molecular dynamics. This study focuses on a propensity of two disaccharides (lactose and sucrose) to ...
• Lactobacillus rhamnosus GG conditioned media modulates acute reactive oxygen species and nitric oxide in J774 murine macrophages. 

  Seenappanahalli Nanjundaiah Y, Wright DA, Baydoun AR, O'Hare WT, Ali Z, Khaled Z, Sarker MH. (Article)

  Phagocytes such as macrophages are capable of detecting and killing pathogenic bacteria by producing reactive oxygen and nitrogen species. Formation of free radicals in macrophages may be regulated by probiotics or by ...
• Quantification of residual crystallinity in ball milled commercially sourced lactose monohydrate by thermo-analytical techniques and terahertz spectroscopy 

  Smith, Geoff ; Hussain, A. ; Bukhari, Nadeem Irfan ; Ermolina, I. (Article)

  The quantification of crystallinity is necessary in order to be able to control the milling process. The use of thermal analysis for this assessment presents certain challenges, particularly in the case of crystal hydrates. ...
• Identification of Potent and Selective CYP1A1 Inhibitors via Combined Ligand and Structure-Based Virtual Screening and Their in Vitro Validation in Sacchrosomes and Live Human Cells. 

  Joshi, Prashant ; McCann, G. J. P. ; Sonawane, V. R. ; Vishwakarma, R. A. ; Chaudhuri, B. ; Bharate, S. B. (Article)

  Target structure-guided virtual screening (VS) is a versatile, powerful, and inexpensive alternative to experimental high-throughput screening (HTS). To discover potent CYP1A1 enzyme inhibitors for cancer chemoprevention, ...
• The use of Quartz Crystal Microbalance as an analytical tool to monitor particles/surface and particle/particle interactions in dry ambient and pressurized conditions: a study using common inhaler components 

  Bloxham, M. ; Chianella, I. ; Turner, N. W. ; Piletsky, S. A. ; Whitcombe, M. J. (Article)

  Metered dose inhalers (MDI) and multidose powder inhalers (MPDI) are commonly used for the treatment of chronic obstructive pulmonary diseases and asthma. Currently, analytical tools to monitor particle/particle and ...
• Detection of multiple steroidal compounds in synthetic urine using comprehensive gas chromatography-mass spectrometry (GC×GC-MS) combined with a molecularly imprinted polymer clean-up protocol 

  Zulfiqar, Adnan ; Morgan, Geraint ; Turner, Nicholas W. (Article)

  method capable of screening for multiple steroids in urine has been developed, using a series of twelve structurally similar, and commercially relevant compounds as target analytes. A molecularly imprinted solid phase ...
• Spotlight on medicinal chemistry education 

  Pitman, Simone ; Xu, Yao ; Taylor, Peter ; Turner, Nicholas (Article)

  The field of medicinal chemistry is constantly evolving and it is important for medicinal chemists to develop the skills and knowledge required to succeed and contribute to the advancement of the field. Future Medicinal ...
• Influence of surface-imprinted nanoparticles on trypsin activity 

  Poma, Alessandro ; Karim, Kal ; Moczko, Ewa ; Takarada, Jessica ; de Vargas-Sansalvador, Isabel ; Piletska, Elena ; Glazova, Natalia ; Serkova, Anastasia ; Omelianova, Aleksandra ; Piletsky, Sergey ; Turner, Nicholas W. ; Guerreiro, Antonio ; de Magalhaes, Cristiana Schmidt (Article)

  Here, the modulation of enzyme activity is presented by protein‐imprinted nanoparticles produced using a solid‐phase approach. Using trypsin as target, binding of the nanoparticles to the enzyme results in its inhibition ...
• Analytical methods for determination of mycotoxins: An update (2009–2014) 

  Turner, Nicholas W.; ; Brahmbhatt, Heli ; Szabo-Vezse, Monika ; Poma, Alessandro ; Coker, Raymond ; Piletsky, Sergey A. (Article)

  Mycotoxins are a problematic and toxic group of small organic molecules that are produced as secondary metabolites by several fungal species that colonise crops. They lead to contamination at both the field and postharvest ...
• Development of sample clean up methods for the analysis of Mycobacterium tuberculosis methyl mycocerosate biomarkers in sputum extracts by gas chromatography–mass spectrometry 

  Turner, Nicholas W. ; Minnikin, David E. ; Lee, Oona Y.-C ; O'Sullivan, Denise M. ; McNerney, Ruth ; Mutetwa, Reggie ; Corbett, Liz E. ; Morgan, Geraint ; Nicoara, Simona C. (Article)

  proof of principle gas chromatography–mass spectrometry method is presented, in combination with clean up assays, aiming to improve the analysis of methyl mycocerosate tuberculosis biomarkers from sputum. Methyl mycocerosates ...
• Polythiophene nanofilms for sensitive fluorescence detection of viruses in drinking water 

  Wankar, Shashwati ; Turner, Nicholas W. ; Krupadam, Reddithota J. (Article)

  Molecular imprints of the tobacco necrosis virus (TNV) have been formed within polythiophene nanofilms with an approximate thickness of 200 nm. These films have been electrochemically deposited onto conducting Au surfaces. ...
• Nucleoside-tailored molecularly imprinted polymeric nanoparticles (MIP NPs) 

  Poma, Alessandro ; Brahmbhatt, Heli ; Watts, Jonathan K ; Turner, Nicholas W. (Article)

  MIP NPs represent one of the current most suitable alternatives to antibodies for molecular recognition and diagnostic applications. Here we present the synthesis of MIP NPs imprinted for 2′-deoxyadenosine (dA) prepared ...
• Generation of novel hybrid aptamer-molecularly imprinted polymeric nanoparticles 

  Poma, Alessandro ; Brahmbhatt, Heli ; Pendergraff, Hannah M ; Watts, Jonathan K ; Turner, Nicholas W. (Article)

  A strategy to exploit aptamers as recognition elements of molecularly imprinted polymeric nanoparticles (AptaMIP NPs) is presented, via modification of the chemical structure of the DNA. It is demonstrated that the ...

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