Leicester School of Pharmacy
Recent Submissions
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Potential Advantages of Peroxoborates and Their Ester Adducts Over Hydrogen Peroxide as Therapeutic Agents in Oral Healthcare Products: Chemical/Biochemical Reactivity Considerations In Vitro, Ex Vivo And In Vivo
(Article)Peroxides present in oral healthcare products generally exert favourable protective activities against the development and progression of tooth decay, plaque, gingivitis, and halitosis, etc. However, despite the high level ... -
Treating infections caused by carbapenemase-producing Enterobacterales (CPE): a pragmatic approach to antimicrobial stewardship on behalf of the UKCPA Pharmacy Infection Network (PIN)
(Article)The emergence of carbapenemase-producing Enterobacterales (CPE) as a major cause of invasive infection both within the UK and internationally poses a very real concern for all providers of healthcare. The burden of morbidity ... -
Analysis of plant secondary metabolism using stable isotope‐labelled precursors
(Article)Introduction Analysis of biochemical pathways typically involves feeding a labelled precursor to an organism, and then monitoring the metabolic fate of the label. Initial studies used radioisotopes as a label and then ... -
Prevalence, determinants and knowledge about herbal medicine and non-hospital utilisation in southwest Nigeria: a cross-sectional study.
(Article)Objectives To examine the prevalence, determinants, safety perceptions, effectiveness and knowledge of herbal medicines (HMs) and reasons for non-hospital utilisation. Design Cross-sectional study. Setting Ekiti ... -
On a Knife Edge: A preliminary investigation of clothing damage using rounded-tip knives
(Article)Bladed weapons are frequently encountered in violent crime offences including street based and armed robberies, murder, sexual assaults and terrorism. A study was conducted involving four frequently encountered clothing ... -
Development of a Silver-Based Dual-Function Antimicrobial Laundry Additive and Textile Coating for the Decontamination of Healthcare Laundry
(Article)Aims: To repurpose a silver-based antimicrobial textile coating product (Micro-Fresh 1911) as a dual-function antimicrobial laundry additive and textile coating. Methods and Results: Survival of Escherichia coli or ... -
Stability of Model Human Coronaviruses on a Range of Textile Fibre Types
(Conference)Previous research indicates that SARS-CoV-2 persists on stainless steel and plastic for 72 hours to 7 days and appears to be less stable on porous surfaces. However, there is limited research on the stability of coronaviruses ... -
Worm-like micelles of triblock copolymer of ethylene oxide and styrene T oxide characterised using light scattering and Taylor dispersion analysis
(Article)A triblock ESE copolymer (E16S8E16, S = styrene oxide and E = ethylene oxide) was synthesised by sequential oxyanionic copolymerisation of styrene oxide followed by ethylene oxide. Light scattering studies demonstrated a ... -
In silico Hierarchical Clustering of Neuronal Populations in the Rat Ventral Tegmental Area Based on Extracellular Electrophysiological Properties
(Article)The ventral tegmental area (VTA) is a heterogeneous brain region, containing different neuronal populations. During in vivo recordings, electrophysiological characteristics are classically used to distinguish the different ... -
Matrix gel
(Other)The present invention relates to a gel having a three dimensional matrix structure and a drug in the form of a solid contained within the three dimensional matrix. Gels of the invention are preferably for implantation ... -
Update on Novel Insulin Technologies
(Conference)The focus here is on the delivery of insulin by formulations that provide an alternative to subcutaneous injection and that rely mainly on gelatinous carrier materials. This will progress to the ideal of delivering an ... -
Novel Insulin Technologies
(Conference)Update on novel insulin technologies The focus here is on the delivery of insulin by formulations that provide an alternative to subcutaneous injection and that rely mainly on gelatinous carrier materials. This will ... -
Quality improvement in community pharmacy: a qualitative investigation of the impact of a postgraduate quality improvement educational module on pharmacists understanding and practice
(Article)Objective Quality improvement (QI) is increasingly featuring in the United Kingdom (UK) National Health Service (NHS) agenda to promote safety, effectiveness and patient experience. However, the use of QI techniques by ... -
Modulation of Macrophage Function by Lactobacillus-Conditioned Medium
(Article)Probiotics are used as microbial food supplements for health and well-being. They are thought to have immunomodulatory effects although their exact physiological mechanism of action is not clear. This study investigated ... -
The role of textiles as fomites in the healthcare environment: A review of the infection control risk
(Article)Background. Infectious diseases are a significant threat in both healthcare and community settings. Healthcare associated infections (HCAIs) in particular are a leading cause of complications during hospitalisation. ... -
Cocrystallisation of Daidzein with pyridine-derived molecules: Screening, structure determination and characterisation
(Article)Daidzein (7,4' -dihydroxyisoflavone, DAI) is an isoflavone found in soybeans and Pueraria. DAI has potential therapeutic benefits on cancer and osteoporosis yet has quite low solubility, limiting its use. Herein a cocrystal ... -
Interaction of Low Molecular Weight Poly(diallyldimethylammonium chloride) and Sodium Dodecyl Sulfate in Low Surfactant–Polyelectrolyte Ratio, Salt-Free Solutions
(Article)Coacervation is widely used in formulations to induce a beneficial character to the formulation, but nonequilibrium effects are often manifest. Electrophoretic NMR (eNMR), pulsed-gradient spin-echo NMR (PGSE-NMR), and ... -
Application of Molecularly Imprinted Polymers in the Anti-Doping Field: Sample Purification and Compound Analysis
(Article)The problem posed by anti-doping requirements is one of the great analytical challenges; multiple compound detection at low ng ml−1 levels from complex samples, with requirements for exceptional confidence in results. This ... -
In vitro and in silico assessment of DNA interaction, topoisomerase I and II inhibition properties of Chrysosplenetin
(Article)Chrysosplenetin is a methoxyflavone with reported anti-cancer effect. We tested its cytotoxic effect on the MCF-7 breast cancer cell line, and determined its effect on DNA intercalation and on the activity of topoisomerases ... -
Through vial impedance spectroscopy (TVIS): A novel approach to process understanding for freeze-drying cycle development
(Book chapter)Through vial impedance spectroscopy (TVIS) provides a new process analytical technology for monitoring a development scale lyophilization process, which exploits the changes in the bulk electrical properties that occur on ...
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