• Nociceptin/orphanin FQ (N/OFQ) modulates immunopathology and airway hyperresponsiveness representing a novel target for the treatment of asthma. 

  Singh, S. R. ; Sullo, N. ; Matteis, M. ; Spaziano, G. ; McDonald, J. ; Saunders, R. ; Woodman, L. ; Urbanek, K. ; De Angelis, A. ; De Palma, R. ; Berair, R. ; Pancholi, M. ; Mistry, V. ; Rossi, F. ; Guerrini, R. ; Calò, G. ; D'Agostino, B. ; Brightling, C. E. ; Lambert, D. G. (Article)

  BACKGROUND AND PURPOSE: There is evidence supporting a role for the nociceptin/orphanin FQ (N/OFQ; NOP) receptor and its endogenous ligand N/OFQ in the modulation of neurogenic inflammation, airway tone and calibre. We ...
• Randomized trial of red cell washing for the prevention of transfusion-associated organ injury in cardiac surgery. 

  Wozniak, M. J. ; Sullo, N. ; Qureshi, S. ; Dott, W. ; Cardigan, R. ; Wiltshire, M. ; Morris, T. ; Nath, M. ; Bittar, N. ; Bhudia, S. K. ; Kumar, T. ; Goodall, A. H. ; Murphy, G. J. (Article)

  BACKGROUND: Experimental studies suggest that mechanical cell washing to remove pro-inflammatory components that accumulate in the supernatant of stored donor red blood cells (RBCs) might reduce inflammation and organ ...
• Flavonoids and Their Metabolites: Prevention in Cardiovascular Diseases and Diabetes 

  Zeka, K. ; Ruparelia, K. C. ; Arroo, R. R. J. ; Budriesi, Roberta ; Micucci, Matteo (Article)

  The occurrence of atherosclerosis and diabetes is expanding rapidly worldwide. These two metabolic disorders often co-occur, and are part of what is often referred to as the metabolic syndrome. In order to determine future ...
• MitoEAGLE preprint 2017-09-21(Version 04). The protonmotive force and respiratory control: Building blocks of mitochondrial physiology Part 1. 

  Moisoi, Nicoleta (Preprint)
• Petals of Crocus sativus L. as a potential source of the antioxidants crocin and kaempferol. 

  Zeka, K. ; Ruparelia, K. C. ; Continenza, M. A. ; Stagos, D. ; Veglio, F. ; Arroo, R. R. J. (Article)

  Saffron fromthe province of L'Aquila, in the Abruzzo region of Italy, is highly prized and has been awarded a formal recognition by the European Union with EU Protected Designation of Origin (PDO) status. Despite this, the ...
• In Vitro Evaluation of Third Generation PAMAM Dendrimer Conjugates 

  Najlah, Mohammad ; Freeman, Sally ; Khoder, Mouhamad ; Attwood, David ; D’Emanuele, Antony (Article)

  The present study compares the use of high generation G3 and low generation G0 Polyamidoamine (PAMAM) dendrimers as drug carriers of naproxen (NAP), a poorly water soluble drug. Naproxen was conjugated to G3 in different ...
• Domestic laundering of nurse’s uniforms: how should uniforms be washed and what are the risks? 

  Riley, K. ; Williams, J. ; Laird, Katie (Article)

  With rises in Healthcare Acquired Infections (HCAIs) and antibiotic resistance understanding possible transmissions routes within the healthcare environment is paramount. One possible route could be textiles and in ...
• Pharmacovigilance and adverse drug reaction reporting: a perspective of community pharmacists and pharmacy technicians in Sana’a, Yemen 

  Al-Worafi, Yaser Mohammed ; Kassab, Yaman Walid ; Alseragi, Wafa Mohammed ; Almutairi, Masaad Saeed ; Ahmed, Ali ; Ming, Long Chiau ; Alkhoshaiban, Ali Saleh ; Hadi, Muhammad Abdul (Article)

  Objective: The aim of this study was to compare the knowledge, attitude and barriers of pharmacy technicians and pharmacists toward pharmacovigilance, adverse drug reactions (ADRs) and ADR reporting in community pharmacies ...
• Development and characterisation of electrospun timolol maleate-loaded polymeric contact lens coatings containing various permeation enhancers 

  Mehta, P. ; Al-Kinani, Ali ; Arshad, Muhammad Sohail ; Chang, Ming-Wei ; Alany, Raid G. ; Ahmad, Z. (Article)

  Despite exponential growth in research relating to sustained and controlled ocular drug delivery; anatomical and chemical barriers of the eye still pose formulation challenges. Nanotechnology integration into the pharmaceutical ...
• 'Treated as a number, not treated as a person': a qualitative exploration of the perceived barriers to effective pain management of patients with chronic pain 

  Hadi, Muhammad Abdul ; Alldred, David Philip ; Briggs, Michelle ; Marczewski, Kathryn ; Closs, S. Jose (Article)

  Objectives To identify barriers to effective pain management encountered by patients with chronic pain within the UK’s National Health Service (NHS). Design Secondary analysis of face-to-face, semistructured qualitative ...
• Quality of reporting of harms in randomised controlled trials of pharmacological interventions for rheumatoid arthritis: a systematic review 

  Hadi, Muhammad Abdul ; McHugh, Gretal A. ; Conaghan, Philip G. (Article)

  Background The quality of reporting of harms data in randomised controlled trials (RCTs) has been reported to be suboptimal. Rheumatoid arthritis (RA) has seen a massive growth in novel pharmacotherapies in the last ...
• Ganoderma lucidum polysaccharide loaded sodium alginate micro-particles prepared via electrospraying in controlled deposition environments 

  Yao, Zhi-Cheng ; Jin, Li-Jie ; Ahmad, Z. ; Huang, Jie ; Chang, Ming-Wei ; Li, Jing-Song (Article)

  Ganoderma lucidum polysaccharide (GLP) is a functional food source deployed in preventative medicine. However, applications utilizing GLP are limited due to oxidative and acidic environmental damage. Advances in preserving ...
• Non-concentric multi-compartment fibers fabricated using a modified nozzle in single-step electrospinning 

  Wang, Baolin ; Wang, Meidi ; Chang, Ming-Wei ; Ahmad, Z. ; Huang, Jie ; Li, Jing-Song (Article)

  Multi-compartment fibers with well-defined regions and functional media hosting potential provide co-encapsulation opportunities for a variety of bio-molecules, drugs and even nutrients. In this research, fibers possessing ...
• Surface modified electrospun porous magnetic hollow fibers using secondary downstream collection solvent contouring 

  Wu, Shuting ; Wang, Baolin ; Ahmad, Z. ; Huang, Jie ; Chang, Ming-Wei ; Li, Jing-Song (Article)

  In this study, a relatively facile porous magnetic hollow fiber engineering electrospinning method is demonstrated, which modulates fiber morphology based on secondary solvents (at variable temperatures). To demonstrate ...
• Essential Oil Bioactive Fibrous Membranes Prepared via Coaxial Electrospinning 

  Yao, Zhi-Cheng ; Chen, Si-Cong ; Ahmad, Z. ; Huang, Jie ; Chang, Ming-Wei ; Li, Jing-Song (Article)

  A novel antimicrobial composite material was prepared by encapsulating orange essential oil (OEO) in zein prolamine (ZP) via the coaxial electrospinning (ES) technique. By manipulating process parameters, the morphological ...
• Controlled Morphing of Microbubbles to Beaded Nanofibers via Electrically Forced Thin Film Stretching 

  Yao, Zhi-Cheng ; Yuan, Qiantailang ; Ahmad, Z. ; Huang, Jie ; Li, Jing-Song ; Chang, Ming-Wei (Article)

  Topography and microstructure engineering are rapidly evolving areas of importance for biomedical and pharmaceutical remits. Here, PVA (Polyvinyl alcohol) microbubbles (diameter range ~126 to 414 μm) were used to fabricate ...
• NMR analysis reveals significant differences in the plasma metabolic profiles of Niemann Pick C1 patients, heterozygous carriers, and healthy controls 

  Probert, Fay ; Ruiz-Rodado, V. ; te Vruchte, Danielle ; Nicoli, Elena-Raluca ; Claridge, Tim D.W. ; Wasif, Christopher ; Farhat, Nicole ; Porter, Forbes D. ; Platt, Frances M. ; Grootveld, M. (Article)

  Niemann-Pick type C1 (NPC1) disease is a rare autosomal recessive, neurodegenerative lysosomal storage disorder, which presents with a range of clinical phenotypes and hence diagnosis remains a challenge. In view of these ...
• Porous Inorganic Drug Delivery Systems—a Review 

  Sayed, E. ; Haj-Ahmad, R. ; Ruparelia, K. C. ; Arshad, M. S. ; Chang, M-W. ; Ahmad, Z. (Article)

  Innovative methods and materials have been developed to overcome limitations associated with current drug delivery systems. Significant developments have led to the use of a variety of materials (as excipients) such as ...
• Flavonoids and Their Metabolites: Prevention in Cardiovascular Diseases and Diabetes. 

  Zeka, K. ; Ruparelia, K. C. ; Arroo, R. R. J. ; Budriesi, Roberta ; Micucci, M. (Article)

  Abstract: The occurrence of atherosclerosis and diabetes is expanding rapidly worldwide. These two metabolic disorders often co-occur, and are part of what is often referred to as the metabolic syndrome. In order to determine ...
• Approaches in topical ocular drug delivery and developments in the use of contact lenses as drug-delivery devices 

  Mehta, P. ; Haj-Ahmad, R. ; Al-Kinani, Ali ; Arshad, Muhammad Sohail ; Chang, Ming-Wei ; Alany, Raid G. ; Ahmad, Z. (Article)

  Drug-delivery approaches have diversified over the last two decades with the emergence of nanotechnologies, smart polymeric systems and multimodal functionalities. The intended target for specific treatment of disease is ...

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