• Self-assembling peptides as an emerging platform for the treatment metabolic syndrome 

  Castillo-Díaz, L.; Ruiz-Pacheco, J.; Elsawy, M.; Reyes-Martínez, J.; Enríquez-Rodríguez, A. (Article)

  Metabolic syndrome comprises a cluster of comorbidities that represent a major risk of developing chronic diseases, such as type II diabetes, cardiovascular diseases, and stroke. Alarmingly, metabolic syndrome reaches ...

• Engaging community pharmacists in quality improvement (QI): a qualitative case study of a partnership between a Higher Education Institute and Local Pharmaceutical Committees 

  Latif, Asam; Gulzar, Nargis; Lowe, Fiona; Ansong, Theo; Gohil, Sejal (Article)

  Background Quality improvement (QI) involves the use of systematic tools and methods to improve the quality of care and outcomes for patients. However, awareness and application of QI among healthcare professionals is poor ...

• The Mycobactin Biosynthesis Pathway: A Prospective Therapeutic Target In The Battle Against Tuberculosis 

  Shyam, Mousumi; Shilkar, Deepak; Verma, Harshita; Dev, Abhimanyu; Sinha, Barij Nayan; Bhakta, Sanjib; Jayaprakash, Venkatesan; Brucoli, Federico (Article)

  The alarming rise in drug-resistant clinical cases of tuberculosis (TB) has necessitated the rapid development of newer chemotherapeutic agents with novel mechanisms of action. The mycobactin biosynthesis pathway, ...

• Staphylococcus aureus internalisation enhances bacterial survival through modulation of host immune responses and mast cell activation 

  Hayes, SM; Holding, RE; Lau, LC; Harries, PG; Allan, RN; Pender, SLF; Walls, AF; Salib, RJ; Biggs, T. C.; Abadalkareem, Rana (Article)

• A therapeutic update on PARP inhibitors: implications in the treatment of glioma 

  Lal, Samridhi; Snape, Tim (Article)

  Central nervous system (CNS) cancers are among the most aggressive and devastating. Furthermore, because of the lack of neuro-oncologists and neurosurgeons in many parts of the world, the specialized treatment ...

• Absorption, Distribution, Metabolism and Excretion (ADME) of Dietary Flavones and Their Glycosides 

  Arroo, Randolph R.J. (Conference)

  Epidemiological studies have long indicated a possible role for dietary flavonoids, notably flavones and flavonols, in the prevention of a range of degenerative diseases, e.g. cancer, diabetes, cardiovascular diseases and ...

• Cannabidiol and cannabigerol inhibit spontaneous contractions in the mouse isolated uterus 

  Brown, James; Teodora, Georgieva; Rajendran, Roshni; Gyeke, Brigitte; Handy, Kirsten; Seifi, Mohsen (Conference)

  Background and Purpose: The production of endocannabionoids andthe presence of cannabinoid receptors in mouse uterus havepreviously been reported (Pagano et al., 2017). Furthermore, we havereported how uterine tissue ...

• Microplastics presence in cultured and wild-caught cuttlefish, Sepia officinalis 

  Hall, Sarah; Oliveira, Ana; Sardinha-Silva, Andreia; Andrews, Paul; Green, Dannielle; Cooke, Gavan; Blackburn, Kirsty; Sykes, António (Article)

  Amongst cephalopods microplastics have been reported only in jumbo squid gut. We investigated microplastics in the digestive system of wild cuttlefish (Sepia officinalis) as they are predators and prey and compared the ...

• Exploring the flammability of emollients and skincare products 

  Hall, Sarah; Blackburn, Kirsty; Morrissey, Jo (Article)

• Recommended antimicrobial therapy for common inpatient infections: a comparative review of guidelines across 51 hospital trusts in England 

  Pan, Daniel; Hills, George; Hamilton, Ashley Ryan; Nash, Tamsin; Hine, Thomas; Whitehorn, Sarah; Barlow, Gavin (Article)

  Background The number of different antimicrobial recommendations between hospital trusts for the same indication in England is unknown. Aim We aimed to evaluate the heterogeneity of antimicrobial recommendations for ...

• Effect of carrier solvent in 1,2-indanedione formulation on the development of fingermarks on porous substrates 

  Zhao, Ya-Bin; Wang, Li-Xue; Li, Wen-Jie; Farrugia, Kevin (Article)

  As an important technique for the detection of fingermarks on porous surfaces, 1,2-indanedione is widely used due to its excellent detection performance. In order to optimize the effectiveness of 1,2-indanedione, several ...

• Effect of polymerisation by microwave on the physical properties of molecularly imprinted polymers (MIPs) specific for caffeine 

  Brahmbhatt, Heli A.; Surtees, Alexander; Tierney, Cavan; Ige, Oluwabukunmi A.; Piletska, Elena V.; Swift, Thomas; Turner, Nicholas W. (Article)

  Molecularly Imprinted Polymers (MIPs) are a class of polymeric materials that exhibit highly specific recognition properties towards a chosen target. These "smart materials" offer robustness to work in extreme environmental ...

• Activity of Antioxidants from Crocus sativus L. Petals: Potential Preventive Effects towards Cardiovascular System 

  Zeka, Keti; Marrazzo, Pasquale; Micucci, Matteo; Ruparelia, Ketan C.; Arroo, Randolph R.J.; Macchiarelli, Guido; Nottola, Stefania Annarita; Continenza, Maria Adelaide; Chiarini, Alberto; Angeloni, Cristina; Hrelia, Silvana; Budriesi, Roberta (Article)

  The petals of the saffron crocus (Crocus sativus L.) are considered a waste material in saffron production, but may be a sustainable source of natural biologically active substances of nutraceutical interest. The aim of ...

• 2-Oxothiazolidine-4-carboxylic acid inhibits vascular calcification via induction of glutathione synthesis 

  Baydoun, Anwar; Patel, J.J.; Bourne, L.E.; Thakur, S.; Farrington, K.; Gorog, D.A.; Orriss, I.R. (Article)

  Arterial medial calcification (AMC), the deposition of hydroxyapatite in the medial layer of the arteries, is a known risk factor for cardiovascular events. Oxidative stress is a known inducer of AMC and endogenous ...

• An integrated model system to gain mechanistic insights into biofilm-associated antimicrobial resistance in Pseudomonas aeruginosa MPAO1 

  Varadarajan, AR; Allan, RN; Valentin, JDP; Castaneda Ocampo, OE; Somerville, V; Pietsch, F; Buhmann, MT; West, J; Skipp, PJ; van der Mei, HC; Ren, Q; Schreiber, F; Webb, JS; Aherns, CH (Article)

  Pseudomonas aeruginosa MPAO1 is the parental strain of the widely utilized transposon mutant collection for this important clinical pathogen. Here, we validate a model system to identify genes involved in biofilm growth ...

• Harnessing the wisdom of crowds can improve guideline compliance of antibiotic prescribers and support antimicrobial stewardship 

  Krockow, Eva; Kurvers, R H J M; Herzog, S M; Kämmer, J E; Hamilton, Ashley Ryan; Thilly, N; Macheda, G; Pulcini, C (Article)

  Antibiotic overprescribing is a global challenge contributing to rising levels of antibiotic resistance and mortality. We test a novel approach to antibiotic stewardship. Capitalising on the concept of “wisdom of crowds”, ...

• Potential Advantages of Peroxoborates and Their Ester Adducts Over Hydrogen Peroxide as Therapeutic Agents in Oral Healthcare Products: Chemical/Biochemical Reactivity Considerations In Vitro, Ex Vivo And In Vivo 

  Grootveld, Martin; Lynch, Edward; Page, Georgina; Chan, W.; Percival, Benita; Anagnostaki, Eugenia; Mylona, Valina; Bordin-Aykroyd, Sonia; Grootveld, Kerry (Article)

  Peroxides present in oral healthcare products generally exert favourable protective activities against the development and progression of tooth decay, plaque, gingivitis, and halitosis, etc. However, despite the high level ...

• Treating infections caused by carbapenemase-producing Enterobacterales (CPE): a pragmatic approach to antimicrobial stewardship on behalf of the UKCPA Pharmacy Infection Network (PIN) 

  Hughes, Stephen; Gilchrist, Mark; Heard, Katie; Hamilton, Ashley Ryan; Sneddon, Jacqueline (Article)

  The emergence of carbapenemase-producing Enterobacterales (CPE) as a major cause of invasive infection both within the UK and internationally poses a very real concern for all providers of healthcare. The burden of morbidity ...

• Analysis of plant secondary metabolism using stable isotope‐labelled precursors 

  Arroo, Randolph R.J.; Bhambra, Avninder S.; Hano, Christophe; Renda, Gülin; Ruparelia, Ketan C.; Wang, Meng F (Article)

  Introduction Analysis of biochemical pathways typically involves feeding a labelled precursor to an organism, and then monitoring the metabolic fate of the label. Initial studies used radioisotopes as a label and then ...

• Prevalence, determinants and knowledge about herbal medicine and non-hospital utilisation in southwest Nigeria: a cross-sectional study. 

  Hall, Sarah; Olujimi, Aina; Gautam, Lata; Padam, Simkhada (Article)

  Objectives To examine the prevalence, determinants, safety perceptions, effectiveness and knowledge of herbal medicines (HMs) and reasons for non-hospital utilisation. Design Cross-sectional study. Setting Ekiti ...

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