• Pharmacy Travel Health Services in Canada: Experience of Early Adopters 

  Thidrickson, Doug; Goodyer, Larry (Article)

  Since 2007, community pharmacists in Canada have become increasingly involved in delivering Travel Health services, including the recommendation and administration of vaccines. This qualitative scoping survey examines ...

• Personalised warfarin dosing in children post cardiac surgery 

  Goodyer, Larry; Rivers, Peter; O'Hare, Linda; Young, Sanfui; Mulla, Hussain; Metwali, B. (Article)

  Warfarin dosing is challenging due to a multitude of factors affecting its pharmacokinetics (PK) and pharmacodynamics (PD). A novel personalised dosing algorithm predicated on a warfarin PK/PD model and incorporating ...

• HIV-1 Activates T Cell Signaling Independently of Antigen to Drive Viral Spread 

  Starling, Shimona; Shivkumar, Maitreyi; Jolly, Clare; Len, Alice C.L. (Article)

  HIV-1 spreads between CD4 T cells most efficiently through virus-induced cell-cell contacts. To test whether this process potentiates viral spread by activating signaling pathways, we developed an approach to analyze the ...

• The HSV-1 Latency-Associated Transcript Functions to Repress Latent Phase Lytic Gene Expression and Suppress Virus Reactivation from Latently Infected Neurons 

  Hann, William; Shivkumar, Maitreyi; Connor, Viv; Efstathiou, Stacey; Nicoll, Michael P.; Harman, Laura E.R.; Coleman, Heather M.; Proenca, Joao T. (Article)

  Herpes simplex virus 1 (HSV-1) establishes life-long latent infection within sensory neurons, during which viral lytic gene expression is silenced. The only highly expressed viral gene product during latent infection is ...

• An Assessment of a Portable Cyanoacrylate Fuming System (LumiFume) for the Development of Latent Fingermarks 

  Jones, Calum; Fraser, Joanna; Deacon, Paul; Lindsay, Maurice; Carlysle-Davies, Felicity; Farrugia, Kevin J (Article)

  The effectiveness and suitability of a portable cyanoacrylate fuming system (LumiFume™) with Lumicyano™ at detecting latent fingermarks was assessed. The first phase of the study compared the LumiFume™ system with traditional ...

• Uraemic serum induced calcification of human aortic smooth muscle cells is a regulated process involving Klotho and RUNX2 

  Patidar, Ashish; Singh, Dhruv; Thakur, Shori; Farrington, Ken; Baydoun, A. (Article)

  Vascular calcification (VC) is common in subjects with chronic kidney disease (CKD) and is associated with increased cardiovascular risk. It is an active process involving trans-differentiation of arterial smooth muscle ...

• Benchtop NMR Spectroscopy and Spectral Analysis of the cis- and trans-Stilbene Products of the Wittig Reaction 

  Edgar, Mark; Percival, Benita; Gibson, Miles; Masania, Jinit; Beresford, Ken; Wilson, Philippe B.; Grootveld, Martin (Article)

  Benchtop NMR spectrometers are now becoming more widely employed in university teaching laboratories. These low-field instruments are increasingly used in reaction monitoring and product purity applications. NMR spectra ...

• Cephalosporin nitric oxide-donor prodrug DEA-C3D disperses biofilms formed by clinical cystic fibrosis isolates of Pseudomonas aeruginosa 

  Soren, O.; Rineh, A.; Silva, D.G.; Cai, Y.; Howlin, R.P.; Allan, Raymond N.; Feelisch, M.; Davies, J.C.; Connett, G.J.; Faust, S.N.; Kelso, M.J.; Webb, J.S. (Article)

  Objectives: The cephalosporin nitric oxide (NO)-donor prodrug DEA-C3D (DiEthylAmin-Cephalosporin-3’- Diazeniumdiolate) has been showed to initiate the dispersal of biofilms formed by Pseudomonas aeruginosa laboratory strain ...

• Errors in DFT Integration Grids and Their Potential Impact on Chemical Shift Calculations 

  Wilson, Philippe B.; Grootveld, M.; Kamerlin, S. C. L. (Article)

• Evaluation of a bio-engineered honey and its synthetic equivalent as novel Staphylococcus aureus biofilm-targeted topical therapies in chronic rhinosinusitis 

  Harries, P. G.; Webb, J.S.; Allan, Raymond N.; Salib, R.J.; Papadopoulou, D.; Dabrowska, A. (Article)

  Background - Chronic rhinosinusitis (CRS) is a common condition which affects the quality of life of millions of patients worldwide and has a significant impact on healthcare resources. Whilst Staphylococcus aureus bacterial ...

• Water-soaked porous evidence: a comparison of processing methods 

  Deacon, Paul; Simmons, Rory K.; Farrugia, Kevin J. (Article)

  This study compared the U.K. Home Office formulation for physical developer (PD) against Oil Red O (ORO) and a modified formulation of physical developer (MPD) that uses Tween 20 instead of Synperonic-N for enhancing ...

• The effect of mark enhancement techniques on the subsequent detection of semen/spermatozoa 

  Deacon, Paul; Phillips, Darren; Farrugia, Kevin J.; Simmons, Rory K. (Article)

  Fingermarks, footwear marks, blood and semen are amongst the most commonly encountered types of evidence at crime scenes. Previous work has extensively investigated fingermark and blood enhancement techniques and a sequence ...

• Pseudo-operational trials of Lumicyano solution and Lumicyano powder for the detection of latent fingermarks on various substrates 

  Fraser, Joanna; Calder, Nicola; Deacon, Paul; Farrugia, Kevin J. (Article)

  This study presents pseudo-operational trials comparing a one-step fluorescent cyanoacrylate process with a number of other enhancement techniques on a variety of substrates. This one-step process involves a product, 4% ...

• Evaluation of Lumicyano cyanoacrylate fuming process for the development of latent fingermarks on plastic carrier bags by means of a pseudo operational comparative trial 

  Deacon, Paul; Fraser, Joanna; Farrugia, Kevin J. (Article)

  There are a number of studies discussing recent developments of a one-step fluorescent cyanoacrylate process. This study is a pseudo operational trial to compare an example of a one-step fluorescent cyanoacrylate product, ...

• Chemical enhancement of soil-based marks on nonporous surfaces followed by gelatin lifting 

  Hammell, Louise; Deacon, Paul; Farrugia, Kevin J. (Article)

  This study assessed the use of processing techniques (potassium thiocyanate, 2-2-dipyridil, potassium ferrocyanide, ammonium pyrrolidinedithiocarbamate, safranin, magnetic powder) for the enhancement of soil-based marks ...

• A review of one-step fluorescent cyanoacrylate techniques 

  Stewart, Vanessa; Deacon, Paul; Farrugia, Kevin J. (Article)

  A review of recent research in the use of one-step fluorescent cyanoacrylate techniques is presented. Advantages and disadvantages of such techniques in comparison to two-step processes are discussed. Further studies and ...

• The effect of cyanoacrylate fuming on subsequent protein stain enhancement of fingermarks in blood 

  Mutter, Nicole; Deacon, Paul; Farrugia, Kevin J. (Article)

  This study investigates the effect of cyanoacrylate (CA) fuming, at atmospheric and vacuum conditions, on subsequent protein stain (acid violet 17) enhancement of fingermarks in blood. Fingermark depletions in blood were ...

• A preliminary investigation into the use of alginates for the lifting and enhancement of fingermarks in blood 

  Munro, Mhairi; Deacon, Paul; Farrugia, Kevin J. (Article)

  Recent studies have reported the use of alginate in the lifting and subsequent enhancement of footwear marks in blood. A study was set up to assess the use of such a method in the treatment of fingermarks in blood on a ...

• An investigation into the detection of latent marks on the feathers and eggs of birds of prey 

  McMorris, Helen; Gentles, Dennis; Farrugia, Kevin J. (Article)

  here are numerous enhancement techniques (physical and chemical) which have been developed for the successful visualisation of latent fingermarks. Nonetheless, problems arise when latent fingermarks require enhancement on ...

• A comparison between atmospheric/humidity and vacuum cyanoacrylate fuming of latent fingermarks 

  Fraser, Joanna; Friel, Laurel; Adams, Duncan; Attard-Montalto, Nicola; Deacon, Paul; Farrugia, Kevin J. (Article)

  A number of pseudo-operational trials were set up to compare the atmospheric/humidity and vacuum cyanoacrylate fuming processes on plastic carrier bags. The fuming processes were compared using two-step cyanoacrylate fuming ...

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