• PuzzlEd 

  Nichols-Drew, L. ; O'Sullivan, Angela ; Crisp, Annette ; Bacon, Joanne ; Bassford, Marie ; Fowler, Mark R. (Conference)

  This interactive workshop showcases the next creative and innovative project, PuzzlEd, being developed by members of the successful Advance HE CATE (Spotlight) 2018 award winners, CrashEd, (Marie Bassford, Joanne Bacon, ...
• Low-Field, Benchtop NMR Spectroscopy as a Potential Tool for Point-of-Care Diagnostics of Metabolic Conditions: Validation, Protocols and Computational Models 

  Percival, B.C. ; Grootveld, M. ; Gibson, M. ; Osman, Y. ; Molinari, M. ; Jafari, F. ; Sahota, T. ; Martin, M. ; Casanova, F. ; Mather, M.L. ; Edgar, M. ; Masania, J. ; Wilson, Philippe B. (Article)

  Novel sensing technologies for liquid biopsies offer promising prospects for the early detection of metabolic conditions through omics techniques. Indeed, high-field nuclear magnetic resonance (NMR) facilities are routinely ...
• Laundering to kill Germs: Microbiological Decontamination of Textiles 

  Laird, Katie (Other)
• A Germ’s Journey- Gujarati Edition 

  Laird, Katie ; Crosby, Sapphire ; Younie, Sarah (Book)
• Experiential Learning as Transformative: Teaching about Genocide and Crimes of the State 

  Sadique, K. ; Tangen, James (Conference)

  The ‘applied nature’ of criminology, criminal justice and law courses lends itself to the use of experiential learning within programme delivery (George et al, 2015; Higgins et al, 2012). What is clear from the limited ...
• Assessing the ex vivo permeation behaviour of functionalised contact lens coatings engineered using an electrohydrodynamic technique 

  Ahmad, Z. ; Alany, Raid G. ; Amoaku, W. M. ; Chang, Ming-Wei ; Alqahtani, Ali ; Arshad, Muhammad Sohail ; Qutachi, Omar ; Al-Kinani, Ali A. ; Mehta, P. (Article)

  In vitro testing alone is no longer considered sufficient evidence presented solely with respect to drug release and permeation testing. These studies are thought to be more reliable and representative when using tissue ...
• Recent advances in exosome-based nanovehicles as RNA interference therapeutic carriers 

  Maheshwari, Rahul ; Tekade, Muktika ; Gondaliya, Piyush ; Kalia, Kiran ; D’Emanuele, Antony ; Tekade, Rakesh Kumar (Article)

  RNA interference (RNAi) therapeutics (siRNA, miRNA, etc.) represent an emerging medicinal remedy for a variety of ailments. However, their low serum stability and low cellular uptake signi cantly restrict their clinical ...
• Engineering and development of chitosan-based Nanocoatings for Ocular Contact Lenses 

  Mehta, P. ; Al-Kinani, Ali A. ; Arshad, Muhammad Sohail ; Singh, Neenu ; van der Merwe, Susanna M. ; Chang, Ming-Wei ; Alany, Raid G. ; Ahmad, Z. (Article)

  The research manuscript reports on Electrohydrodynamic Atomisation (EHDA) to engineer on-demand novel coatings for ocular contact lenses. A formulation approach was adopted to modulate the release of timolol maleate (TM) ...
• Φ-order spectrophotokinetic characterisation and quantification of trans-cis oxyresveratrol reactivity, photodegradation and actinometry. 

  Maafi, Mounir ; Alqarni, M. (Article)

  A new Φ-order kinetic method was proposed in this study for the investigation of trans-cis photoisomerization reaction of Oxyresveratol (ORVT) subjected to non-isosbestic irradiation. In ethanolic media, it has been proven ...
• Quinazoline derivatives as selective CYP1B1 inhibitors 

  Siddique, Mohd Usman Mohd ; McCann, Glen J. P. ; Sonawane, Vinay ; Horley, Neill ; Gatchie, Linda ; Joshi, Prashant ; Bharate, Sandip B. ; Jayaprakash,Venkatesan ; Sinha, Barij N. ; Chaudhuri, B. (Article)

  CYP1B1 is implicated to have a role in the development of breast, ovarian, renal, skin and lung carcinomas. It has been suggested that identification of potent and specific CYP1B1 inhibitors can lead to a novel treatment ...
• Pharmaceutical excipients properties and screw feeder performance in continuous processing lines: a Quality by Design (QbD) approach 

  Santos, B. ; Carmo, F. ; Schlindwein, W. S. ; Muirhead, G. ; Rodriguez, C. ; Cabral, L. ; Westrup, J. ; Pitt, K. (Article)

  Screw feeder performance is a critical aspect in continuous manufacturing processes. Pharmaceutical excipients, such as mannitol, microcrystalline cellulose, lactose monohydrate, and anhydrous dibasic calcium phosphate can ...
• Solubility and dissolution rate enhancement of ibuprofen by co-milling with polymeric excipients 

  Smith, Geoff ; Pedge, Nicholas ; Khan, Karrar A ; Bukhari, Nadeem Irfan ; Hussain, Amjad ; Ermolina, I. (Article)

  The aim of this study was to enhance the kinetic solubility and dissolution rate of ibuprofen by co-milling with different excipients and to establish the underlying mechanism(s) for such enhancement. In the first-part, ...
• Montelukast photodegradation: Elucidation of Ф-order kinetics, determination of quantum yields and application to actinometry. 

  Maafi, W. ; Maafi, Mounir (Article)

  A recently developed F–order semi–emperical integrated rate–law for photoreversible AB(2F) photoreversible reactions has been successfully applied to investigate Montelukast sodium (Monte) photodegradation kinetics in ...
• Correlation between molecular dynamics and physical stability of two milled anhydrous sugars: lactose and sucrose 

  Smith, Geoff ; Hussain, Amjad ; Bukhari, Nadeem Irfan ; Ermolina, I. (Article)

  The process of milling often results in amorphization and the physical stability of amorphous phase is linked with its molecular dynamics. This study focuses on a propensity of two disaccharides (lactose and sucrose) to ...
• Lactobacillus rhamnosus GG conditioned media modulates acute reactive oxygen species and nitric oxide in J774 murine macrophages. 

  Seenappanahalli Nanjundaiah, Y. ; Wright, D. A. ; Baydoun, A. ; O'Hare, W. T. ; Ali, Z. ; Khaled, Z. ; Sarker, M. H. (Article)

  Phagocytes such as macrophages are capable of detecting and killing pathogenic bacteria by producing reactive oxygen and nitrogen species. Formation of free radicals in macrophages may be regulated by probiotics or by ...
• Quantification of residual crystallinity in ball milled commercially sourced lactose monohydrate by thermo-analytical techniques and terahertz spectroscopy 

  Smith, Geoff ; Hussain, A. ; Bukhari, Nadeem Irfan ; Ermolina, I. (Article)

  The quantification of crystallinity is necessary in order to be able to control the milling process. The use of thermal analysis for this assessment presents certain challenges, particularly in the case of crystal hydrates. ...
• Identification of Potent and Selective CYP1A1 Inhibitors via Combined Ligand and Structure-Based Virtual Screening and Their in Vitro Validation in Sacchrosomes and Live Human Cells. 

  Joshi, Prashant ; McCann, G. J. P. ; Sonawane, V. R. ; Vishwakarma, R. A. ; Chaudhuri, B. ; Bharate, S. B. (Article)

  Target structure-guided virtual screening (VS) is a versatile, powerful, and inexpensive alternative to experimental high-throughput screening (HTS). To discover potent CYP1A1 enzyme inhibitors for cancer chemoprevention, ...
• The use of Quartz Crystal Microbalance as an analytical tool to monitor particles/surface and particle/particle interactions in dry ambient and pressurized conditions: a study using common inhaler components 

  Bloxham, M. ; Chianella, I. ; Turner, N. W. ; Piletsky, S. A. ; Whitcombe, M. J. (Article)

  Metered dose inhalers (MDI) and multidose powder inhalers (MPDI) are commonly used for the treatment of chronic obstructive pulmonary diseases and asthma. Currently, analytical tools to monitor particle/particle and ...
• Detection of multiple steroidal compounds in synthetic urine using comprehensive gas chromatography-mass spectrometry (GC×GC-MS) combined with a molecularly imprinted polymer clean-up protocol 

  Zulfiqar, Adnan ; Morgan, Geraint ; Turner, Nicholas W. (Article)

  method capable of screening for multiple steroids in urine has been developed, using a series of twelve structurally similar, and commercially relevant compounds as target analytes. A molecularly imprinted solid phase ...
• Spotlight on medicinal chemistry education 

  Pitman, Simone ; Xu, Yao ; Taylor, Peter ; Turner, Nicholas (Article)

  The field of medicinal chemistry is constantly evolving and it is important for medicinal chemists to develop the skills and knowledge required to succeed and contribute to the advancement of the field. Future Medicinal ...

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