• Assessment of chalcones as cancer chemopreventive agents 

  Jasim, Hiba ; Sarker, Satyajit Dey ; Moore, Sharon ; Ruparelia, K. C. ; Arroo, R. R. J. ; Ritchie, Kenneth (Conference)

  Chemoprevention is based upon the use of natural or synthetic products to eliminate or minimize the development of cancer1. Many cancers are thought to occur due to processes such as oxidative stress and lipid peroxidation ...
• Discovery and characterization of novel CYP1B1 inhibitors based on heterocyclic chalcones: Overcoming cisplatin resistance in CYP1B1-overexpressing lines 

  Horley, Neill ; Beresford, Kenneth J. M. ; Chawla, Tarun ; McCann, Glen J. P. ; Ruparelia, K. C. ; Gatchie, Linda ; Sonawane, Vinay ; Williams, Vinay R. ; Tan, Hoon Leong ; Joshi, Prashant ; Bharate, Sonali S. ; Kumar, Vikas ; Bharate, Sandip B. ; Chaudhuri, Bhabatosh (Article)

  The structure of alpha-napthoflavone (ANF), a potent inhibitor of CYP1A1 and CYP1B1, mimics the structure of chalcones. Two potent CYP1B1 inhibitors 7k (DMU2105) and 6j (DMU2139) have been identified from two series of ...
• Pyrogallol is the main antibacterial compound in the aqueous extract of Boswellia dalzielii bark 

  Alfa, Hajara ; Arroo, R. R. J. ; Walsh, Susannah ; Ruparelia, K. C. ; Bhambra, Avninder S. ; Slater, Adrian (Presentation)

  Plants belonging to the genus Boswellia (Burseraceae) have long been appreciated for their pharmacological properties such as anti-inflammatory, antioxidative and anticancer activities1. In the Northern part of Nigeria, ...
• A computational study of the influence of methyl substituents on competitive ring closure to α- and β-lactones 

  Wilson, Philippe B. ; Williams, Ian H. (Article)

  Ring-closure of substituted 2-chlorosuccinates to α- or β-lactones has been studied by means of MP2/6-311+G(d,p)//MP2/6-31+G(d) calculations in water treated as a polarised continuum (PCM) and in vacuum. Optimised geometries ...
• Effects of Novel Chalcone Derivatives upon H9c2 and MDCK Cell Viability 

  Hussain, A. ; Wright, Jack ; Ruparelia, K. C. ; Beresford, Kenneth J. M. ; Fretwell, L. (Conference)

  Many compounds with potential anti-cancer activity fail to reach the latter stages of clinical trials due to adverse effects, often causing cardiac and renal toxicity. Here, we synthesised a group of novel chalcone ...
• Domestic Laundering of Nurses Uniforms: The Effect of Low Temperature Laundering 

  Laird, Katie (Presentation)
• Hygiene of Domestic Laundering – Evaluating Risks and Opportunities 

  Laird, Katie (Presentation)
• The provision of prescription only medicines for use on United Kingdom based overseas expeditions 

  Moore, James K. ; Ladbrook, Matthew ; Goodyer, Larry ; Dallimore, Jon (Article)

  Expedition teams without accompanying medical professionals traveling overseas from the United Kingdom frequently carry medical kits containing Prescription Only Medicines (POMs). Access to safe, basic POMs whilst on ...
• Metabolism of steroidal lactones by the fungus Corynespora cassiicola CBS 161.60 results in a mechanistically unique intramolecular ring-D cyclization resulting in C-14 spiro-lactones 

  Hunter, Alan Christy ; Oni, Yewande Inatimi ; Dodd, Howard T. ; Raftery, James ; Gardiner, John M. ; Uttley, Megan (Article)

  The fungus Corynespora cassiicola metabolises exogenous steroids in a unique and highly specific manner. Central to this, is the ability of this organism to functionalise substrates (androgens, progestogens) at the highly ...
• Bypassing particle-mediated adverse injection reactions through shape modification and erythrocyte ‘hitch-hiking’ 

  Wibroe, Peter P. ; Anselmo, Aaron C. ; Nilsson, Per H. ; Gupta, Vivek ; Urbanics, Rudolf ; Szebeni, Janos ; Hunter, Alan Christy ; Mitragotri, Samir ; Mollnes, Tom Eirik ; Moghimi, S. M. (Article)

  Intravenously injected nanopharmaceuticals induce adverse cardiopulmonary reactions in sensitive human subjects and these reactions are reproducible in pigs. The underlying mechanisms are poorly understood, but a role for ...
• Recent Advances in Avian Egg Science: A Review 

  Wilson, Philippe B. (Article)

  Eggs and egg products form an integral part of the food chain. As such, research into egg structure, function, and production has made an important contribution to the field of poultry science. The past decade has seen ...
• Determination of Heavy Metals Present in the Hypoglycemic Karela Powder: An Analytical Assay 

  Ruparelia, K. C. ; Wilson, Philippe B. ; Sousa, M. C. ; Juma, Nazmin ; Desai, Unmesh ; Grootveld, M. ; Arroo, R. R. J. ; Zeka, K. (Article)

  Diabetes is a common health condition associated with heightened glucose content in the blood due to impaired insulin production/function. Considering current societal trends, the number of patients with this condition is ...
• Writing a paper: a guide for early career researchers Part 2 

  Allen, Susan (Article)
• Writing a paper: a guide for early career researchers Part 1. 

  Allen, Susan (Article)
• Self-care: a model for consultation 

  Allen, Susan (Article)
• Chronic methylphenidate regulates genes and proteins mediating neuroplasticity in the juvenile brain 

  Quansah, Emmanuel ; Sgamma, Tiziana ; Jaddoa, Estabraq ; Zetterstrom, T. S. C. (Article)

  Methylphenidate (MPH) is the front-line psychostimulant medication prescribed for alleviating the symptoms associated with attention deficit hyperactivity disorder (ADHD) in children. Here, we investigated the effects of ...
• The Fight Against Germs 

  Laird, Katie ; Younie, Sarah (Other)
• Cmr is a redox-responsive regulator of DosR that contributes to M. tuberculosis virulence. 

  Smith, Laura J. ; Bochkareva, Aleksandra ; Rolfe, Matthew D. ; Hunt, Debbie M. ; Kahramanoglou, Christina ; Braun, Yvonne ; Rodgers, Angela ; Blockley, Alix ; Coade, Stephen ; Lougheed, Kathryn E. A. ; Hafneh, Nor Azian ; Glenn, Sarah M. ; Crack, Jason C. ; Le Brun, Nick E. ; Saldanha, José W. ; Makarov, Vadim ; Nobeli, Irene ; Arnvig, Kristine ; Mukamolova, Galina V. ; Buxton, Roger S. ; Green, Jeffrey (Article)

  Mycobacterium tuberculosis (MTb) is the causative agent of pulmonary tuberculosis (TB). MTb colonizes the human lung, often entering a non-replicating state before progressing to life-threatening active infections. ...
• Qualitative and Qualitative Phytochemical Screening of Medicinal Herbal Ocimum Tulsi Leaves 

  Ruparelia, K. C. ; Arroo, R. R. J. ; Grootveld, M. ; Zeka, K. ; Mali, Purvi ; Alfa, Hajara ; Juma, Nazmin ; Desai, Unmesh ; Ali, Zainab (Conference)

  The drastic changes in human life style and food habits over the last century have led to various chronic diseases. Diabetes milletus is one such disease, which is causing serious problems to human health in all parts of ...
• Process Analytical Technology and the Question of Scale 

  Smith, Geoff (Conference)

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