• Herpes Simplex Virus 1 Interaction with Myeloid Cells In Vivo 

  Shivkumar, Maitreyi; Lawler, Clara; Milho, Ricardo; Stevenson, Philip G. (Article)

  Herpes simplex virus 1 (HSV-1) enters mice via olfactory epithelial cells and then colonizes the trigeminal ganglia (TG). Most TG nerve endings are subepithelial, so this colonization implies subepithelial viral spread, ...

• Towards equity: a qualitative exploration of the implementation and impact of a digital educational intervention for pharmacy professionals in England 

  Latif, Asam; Waring, Justin; Pollock, Kristian; Solomon, Josie; Gulzar, Nargis; Choudhary, Shahida; Anderson, Claire (Article)

  Background Patients belonging to marginalised (medically under-served) groups experience problems with medicines (i.e. non-adherence, side effects) and poorer health outcomes largely due to inequitable access to healthcare ...

• Supporting the provision of pharmacy medication reviews to marginalised (medically underserved) groups: a before/after questionnaire study investigating the impact of a patient–professional co-produced digital educational intervention 

  Latif, Asam; Waring, Justin; Chen, Li-chia; Pollock, Kristian; Solomon, Josie; Gulzar, Nargis; Gulzar, Sulma; Anderson, Emma; Choudhary, Shahida; Abbasi, Nasa; Wharrad, Heather; Anderson, Claire (Article)

  Objectives People who are marginalised (medically underserved) experience significant health disparities and their voices are often ‘seldom heard’. Interventions to improve professional awareness and engagement with these ...

• 2-furyl(phenyl)methanol isolated from Atractilis gummifera rhizome exhibits anti-leishmanial activity 

  Deiva, Solene; Ferguson, Lindsay; Rateb, Mostafa; Williams, Roderick; Brucoli, Federico (Article)

  We report for the first time the isolation of 2-furyl(phenyl)methanol (5) from the chloroform extracts of the Atractylis gummifera roots. A. gummifera is a thistle belonging to the Asteraceae family that produces the ...

• Through-Vial Impedance Spectroscopy (TVIS): A New Method for Determining the Ice Nucleation Temperature and the Solidification End Point 

  Smith, Geoff; Jeeraruangrattana, Yowwares (Book chapter)

• Insulin Solution Stability and Biocompatibility with Materials Used for an Implantable Insulin Delivery Device Using Reverse Phase HPLC Methods 

  Jacob, Dolly; Tomlins, Paul; Taylor, M. Joan; Sahota, T. S. (Article)

  Abstract: Insulin (Humulin® R IU500) has been delivered from an implantable artificial pancreas in diabetic rats and pigs. The artificial pancreas which was implanted in the peritoneum was fabricated from several ...

• miRNAs as Regulators of Antidiabetic Effects of Fucoidans 

  Zhao, Chao; Lai, Shanshan; Wu, Desheng; Liu, Dan; Zou, Xiaobo; Ismail, Amin; El-Seed, Hesham; Arroo, Randolph R.J.; Xiao, Jianbo (Article)

  Diabetes mellitus is a metabolic disease with a high mortality rate worldwide. MicroRNAs (miRNAs), and other small noncoding RNAs, serve as endogenous gene regulators through binding to specific sequences in RNA and modifying ...

• The optimisation of fingermark enhancement by VMD and Lumicyano™ on thermal paper 

  Sherriffs, Paul; Fraser, Joanna; Farrugia, Kevin J.; Jones, Benjamin J. (Article)

  The enhancement of fingermarks on thermal paper can be challenging due to background staining caused by polar solvents used in fingermark enhancement techniques such as ninhydrin. This study explored a commercial one-step ...

• A review of Fourier Transform Infrared (FTIR) spectroscopy used in food adulteration and authenticity investigations 

  Valand, Reema; Tanna, Sangeeta; Lawson, Graham; Bengtstrom, Linda (Article)

  The increasing demand for food and the globalisation of the supply chain, have resulted in a rise in food fraud, and recent high profile cases, such as the Chinese milk scandal in 2008 and the EU horsemeat scandal in 2013 ...

• Niemann-Pick type C disease: cellular pathology and pharmacotherapy 

  Wheeler, S.; Sillence, Daniel J. (Article)

  Niemann-Pick type C disease (NPCD) was first described in 1914 and affects approximately 1 in 150,000 live births. It is characterised clinically by diverse symptoms affecting liver, spleen, motor control and brain; premature ...

• Heterogeneous Fenton's-like catalysis for degradation of colchicine coupled with extraction of its biologically active metabolite 

  Huddersman, Katherine; Hosny, Noha M.; Atia, Noha N.; El-Gizawy, Samia M. (Article)

  Nowadays, drug pollution; a form of water pollution caused by some pharmaceuticals and their metabolites resulting from consumers, industry and hospitals was reported. Colchicine (CLN) is considered one of the ...

• Pharmacy Travel Health Services in Canada: Experience of Early Adopters 

  Thidrickson, Doug; Goodyer, Larry (Article)

  Since 2007, community pharmacists in Canada have become increasingly involved in delivering Travel Health services, including the recommendation and administration of vaccines. This qualitative scoping survey examines ...

• Personalised warfarin dosing in children post cardiac surgery 

  Goodyer, Larry; Rivers, Peter; O'Hare, Linda; Young, Sanfui; Mulla, Hussain; Metwali, B. (Article)

  Warfarin dosing is challenging due to a multitude of factors affecting its pharmacokinetics (PK) and pharmacodynamics (PD). A novel personalised dosing algorithm predicated on a warfarin PK/PD model and incorporating ...

• HIV-1 Activates T Cell Signaling Independently of Antigen to Drive Viral Spread 

  Starling, Shimona; Shivkumar, Maitreyi; Jolly, Clare; Len, Alice C.L. (Article)

  HIV-1 spreads between CD4 T cells most efficiently through virus-induced cell-cell contacts. To test whether this process potentiates viral spread by activating signaling pathways, we developed an approach to analyze the ...

• The HSV-1 Latency-Associated Transcript Functions to Repress Latent Phase Lytic Gene Expression and Suppress Virus Reactivation from Latently Infected Neurons 

  Hann, William; Shivkumar, Maitreyi; Connor, Viv; Efstathiou, Stacey; Nicoll, Michael P.; Harman, Laura E.R.; Coleman, Heather M.; Proenca, Joao T. (Article)

  Herpes simplex virus 1 (HSV-1) establishes life-long latent infection within sensory neurons, during which viral lytic gene expression is silenced. The only highly expressed viral gene product during latent infection is ...

• An Assessment of a Portable Cyanoacrylate Fuming System (LumiFume) for the Development of Latent Fingermarks 

  Jones, Calum; Fraser, Joanna; Deacon, Paul; Lindsay, Maurice; Carlysle-Davies, Felicity; Farrugia, Kevin J. (Article)

  The effectiveness and suitability of a portable cyanoacrylate fuming system (LumiFume™) with Lumicyano™ at detecting latent fingermarks was assessed. The first phase of the study compared the LumiFume™ system with traditional ...

• Uraemic serum induced calcification of human aortic smooth muscle cells is a regulated process involving Klotho and RUNX2 

  Patidar, Ashish; Singh, Dhruv; Thakur, Shori; Farrington, Ken; Baydoun, A. (Article)

  Vascular calcification (VC) is common in subjects with chronic kidney disease (CKD) and is associated with increased cardiovascular risk. It is an active process involving trans-differentiation of arterial smooth muscle ...

• Benchtop NMR Spectroscopy and Spectral Analysis of the cis- and trans-Stilbene Products of the Wittig Reaction 

  Edgar, Mark; Percival, Benita; Gibson, Miles; Masania, Jinit; Beresford, Ken; Wilson, Philippe B.; Grootveld, Martin (Article)

  Benchtop NMR spectrometers are now becoming more widely employed in university teaching laboratories. These low-field instruments are increasingly used in reaction monitoring and product purity applications. NMR spectra ...

• Cephalosporin nitric oxide-donor prodrug DEA-C3D disperses biofilms formed by clinical cystic fibrosis isolates of Pseudomonas aeruginosa 

  Soren, O.; Rineh, A.; Silva, D.G.; Cai, Y.; Howlin, R.P.; Allan, Raymond N.; Feelisch, M.; Davies, J.C.; Connett, G.J.; Faust, S.N.; Kelso, M.J.; Webb, J.S. (Article)

  Objectives: The cephalosporin nitric oxide (NO)-donor prodrug DEA-C3D (DiEthylAmin-Cephalosporin-3’- Diazeniumdiolate) has been showed to initiate the dispersal of biofilms formed by Pseudomonas aeruginosa laboratory strain ...

• Errors in DFT Integration Grids and Their Potential Impact on Chemical Shift Calculations 

  Wilson, Philippe B.; Grootveld, M.; Kamerlin, S. C. L. (Article)

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