Browsing School of Allied Health Sciences by Title
Now showing items 843-862 of 1274
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P2RX7 purinoceptor as a therapeutic target – the second coming?
(Article)The P2RX7 receptor is a unique member of a family of extracellular ATP (eATP)-gated ion channels expressed in immune cells, where its activation triggers the inflammatory cascade. Therefore, P2RX7 has been long investigated ... -
P2RX7 Purinoceptor: A Therapeutic Target for Ameliorating the Symptoms of Duchenne Muscular Dystrophy
(Article)Duchenne muscular dystrophy (DMD) is the most common inherited muscle disease, leading to severe disability and death in young men. Death is caused by the progressive degeneration of striated muscles aggravated by sterile ... -
P2X receptor signalling in skeletal muscle health and disease
(Article)Skeletal muscle (SM) is a heterogeneous and dynamic tissue that changes significantly in its form and function in response to external and internal stimuli and throughout life, from development right through to aging. ... -
P2X7 purinoceptor alterations in dystrophic mdx mouse muscles: Relationship to pathology and potential target for treatment.
(Article)Duchenne muscular dystrophy (DMD) is a lethal inherited muscle disorder. Pathological characteristics of DMD skeletal muscles include, among others, abnormal Ca2 homeostasis and cell signalling. Here, in the mdx mouse model ... -
Pathology and Gene Expression in the Uteri of Mice Dosed with Oestradiol and Tamoxifen.
(Conference)There is a marked difference in the development of uterine pathologies following administration of tamoxifen to neonatal mice by different routes. Oral dosing causes adenomyosis while subcutaneous administration results ... -
Patients embodied and as-a-body within bedside teaching encounters: A video ethnographic study
(Article)Bedside teaching encounters (BTEs) involve doctor–patient–student interactions, providing opportunities for students to learn with, from and about patients. How the differing concerns of patient care and student education ... -
Peer assistance in an English immersion context in China.
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People with aphasia creating an aphasia friendly website: The DMU4 experience
(Conference / Image)People with aphasia creating an aphasia friendly website: The DMU4 experience Bixley,M., DMU4, Hall, R., Weale, R., Collingwood, J., Marshall, F. & Hamilton, C. Background Information The DMU4 Conversation group is ... -
The personalisation of dementia services and existential realities: understanding Sikh carers caring for an older person with dementia in Wolverhampton
(Article)While personalisation and service choice remains a central plank of the Labour Government’s policies in health and social care, there is a growing evidence base confirming that ethnic minority groups, are disadvantaged as ... -
Pharmacology of the metabotropic GluR-mediated current at the climbing fiber to Purkinje cell synapse
(Conference)Different forms of synaptic plasticity in the cerebellum are mediated by metabotropic glutamate receptors (mGluRs). At parallel fiber (PF) to Purkinje cell (PC) synapses activation of mGluR gives rise to a well known slow ... -
Pharmacology of the metabotropic glutamate receptor mediated current at the climbing fiber to Purkinje cell synapse.
(Article)Different forms of synaptic plasticity in the cerebellum are mediated by metabotropic glutamate receptors (mGluRs). At parallel fiber (PF) to Purkinje cell (PC) synapses activation of mGluR gives rise to a well known slow ... -
Phenotypic and genotypic identification of urinary tract infections caused by E. coli in the Leicestershire area.
(Conference)Backgrounds Uropathogenic E. coli is one of the highest producers of ESBLs (Extended-spectrum β-lactamases), a major public health concern. Objectives This study aims to investigate the prevalence of ESBLs and plasmid ... -
Phonetic variation in dysarthric speech as a function of sampling task.
(Article)Previous studies have demonstrated a number of ways in which normal speakers' phonetic performance varies across reading and spontaneous speech tasks. This study set out to investigate whether similar differences across ... -
Phosphine generation by mixed- and monoseptic-cultures of anaerobic bacteria.
(Article)A microbial basis for bioreductive generation of phosphine is proposed, which could account at least in part for the presence of this toxic gas in natural anaerobic environments and in sewage and landfill gases. Phosphine ...