School of Allied Health Sciences
Recent Submissions
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DNA Authentication of St John’s Wort (Hypericum perforatum L.) Commercial Products Targeting the ITS Region
(Article)There is considerable potential for the use of DNA barcoding methods to authenticate raw medicinal plant materials, but their application to testing commercial products has been controversial. A simple PCR test targeting ... -
Compound heterozygous ZMPSTE24 mutations reduce prelamin A processing and result in a severe progeroid phenotype
(Article)Hutchinson–Gilford progeria syndrome (HGPS) is a rare but devastating genetic disorder that mimics premature aging. Most cases are caused by heterozygous mutations in LMNA, encoding lamin A/C. The allelic disorder, ... -
SUN1 interacts with nuclear lamin A and cytoplasmic nesprins to provide a physical connection between the nuclear lamina and the cytoskeleton
(Article)Nuclear migration and positioning within cells are critical for many developmental processes and are governed by the cytoskeletal network. Although mechanisms of nuclear-cytoskeletal attachment are unclear, growing evidence ... -
Hutchinson-Gilford progeria syndrome: clinical findings in three patients carrying the G608G mutation in LMNA and review of the literature.
(Article)Hutchinson-Gilford progeria syndrome (HGPS) is a rare premature ageing disorder that belongs to a group of conditions called laminopathies which affect nuclear lamins. Classical and atypical forms of HGPS have been reported ... -
Mammalian SUN protein interaction networks at the inner nuclear membrane and their role in laminopathy disease processes
(Article)The nuclear envelope (NE) LINC complex, in mammals comprised of SUN domain and nesprin proteins, provides a direct connection between the nuclear lamina and the cytoskeleton, which contributes to nuclear positioning and ... -
Lamin A-linked progerias: is farnesylation the be all and end all?
(Article)HGPS (Hutchinson-Gilford progeria syndrome) is a severe childhood disorder that appears to mimic an accelerated aging process. The disease is most commonly caused by gene mutations that disrupt the normal post-translational ... -
An observational cohort feasibility study to identify microvesicle and miRNA biomarkers of acute kidney injury following paediatric cardiac surgery
(Article)Objectives: Micro-RNA, small noncoding RNA fragments involved in gene regulation, and microvesicles, membrane-bound particles less than 1 μm known to regulate cellular processes including responses to injury, may serve ... -
Morbid curiosity? Discussion of the disposal of amputated limbs on online question and answer sites
(Article)Amputation is a growing health issue with implications for the corporeal form and sense of bodily identity. Disposal of the removed limb (the amputate) has historically been suggested to impact upon patient adaptation to ... -
Transnational Inclusive Mental Health De-Stigmatising Education (TIMHDE): An exploration of the means to engage global communities in mental health de-stigmatisation.
(Conference)The World Health Organisation (WHO) acknowledged high income countries often address mental health discrimination, but low/middle income countries often had a significant gap in how they measure the problem, and in strategies, ... -
Evaluation of the Proximity of Singaporean Children’s Dietary Habits to Food-Based Dietary Guidelines
(Article)Dietary habits in children may not only impact on current health status but could also shape future, lifelong dietary choices. Dietary intake data in Singaporean children are limited. The current study aimed to use existing ... -
Transnational Inclusive Mental Health De-Stigmatising Education (TIMHDE): An exploration of the means to engage global communities in mental health de-stigmatisation
(Conference)Some countries embrace, others exclude the mentally ill. The World Health Organisation (WHO) acknowledged high income countries often address this, but low/middle income countries often had a significant gap in how they ... -
The Differential DNA Hypermethylation Patterns of microRNA-137 and microRNA-342 Locus in Early Colorectal Lesions and Tumours.
(Article)Colorectal cancer (CRC) is the third most commonly diagnosed cancer worldwide, representing 13% of all cancers. The role of epigenetics in cancer diagnosis and prognosis is well established. MicroRNAs in particular influence ... -
Biosocial Model of Disability
(Book chapter)This chapter began with an introduction to disability and aging as part of the global human condition. It is then argued that a disability perspective is critical to understanding different ways people are aging and those ... -
The social construction of male infertility: A qualitative questionnaire study of men with a male factor infertility diagnosis
(Article)Although recent research has highlighted the distressing impact of infertility for men, fertility issues are still routinely seen as a ‘women’s issue’ – even when male factor infertility is highlighted. This paper reports ... -
The role of two-pore channels in norepinephrine-induced [Ca2+]i rise in rat aortic smooth muscle cells and aorta contraction.
(Article)Second messenger nicotinic acid adenine dinucleotide phosphate (NAADP) triggers Ca2+ release via two-pore channels (TPCs) localized in endolysosomal vesicles. The aim of the present work is to evaluate the role of TPCs ... -
Heme binding to human CLOCK affects interactions with the E-box
(Article)The circadian clock is an endogenous time-keeping system that is ubiquitous in animals and plants as well as some bacteria. In mammals, the clock regulates the sleep-wake cycle via 2 basic helix-loop-helix PER-ARNT-SIM ... -
Safety and toxicity evaluation of nutraceuticals in animal models.
(Book chapter)Nutraceuticals are derived from various natural sources such as medicinal plants, marine organisms, vegetables, and fruits. Most of them possess antioxidant or anti-inflammatory properties and are claimed to provide ... -
The impact of infertility on men’s work and finances: Findings from a qualitative questionnaire study
(Article)The impact of infertility on the emotional, social and relational aspects of men’s lives is now more widely understood. Yet the impact of infertility on men’s working lives and financial status remains largely overlooked. ... -
Hyperhidrosis Priority Setting Partnership: the top 10 research priorities for management and treatment of hyperhidrosis.
(Conference)Hyperhidrosis is a common skin condition characterised by abnormal levels of sweating, and affects 1 -3 % of the population. It can cause both physical problems and psychological distress, and significantly affect quality ... -
First detection of Acanthamoeba spp. and Balamuthia mandrillaris in different water ecosystems in Leicestershire (UK).
(Conference)Acanthamoeba spp., Naegleria fowleri and Balamuthia mandrillaris can produce severe brain infections in immunocompetent and immunocompromised individuals. These free‐living amoebae (FLA) have a worldwide distribution. ...
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