Variants of the peroxisome proliferator-activated receptor g- and b-adrenergic receptor genes are associated with measures of compensatory eating behaviors in young children.
Date
2007Author
Abstract
Background: Young children can regulate energy precisely in the
short term, showing the potential for an innate compensation mechanism
of eating behavior. However, data suggest that precise compensation
is attenuated as a function of increasing adiposity, parental
feeding style, and age.Commonvariation in candidate obesity genes
may account for some of the individual variation observed in shortterm
energy compensation. Polymorphisms in the peroxisome
proliferator-activated receptor (PPARG) and -adrenergic receptor
(ADRB3) genes have been linked to increased body mass index
(BMI; in kg/m2), obesity, and more recently dietary nutrients and
preferences. In addition, common variation in ADRB3 interacts with
PPARG to modulate adult body weight.
Objective: This study investigated whether variants in these genes
were associated with measurable effects on child eating behavior.
Design: Children (n 84) aged 4–10 y were prospectively selected
for variants of the PPARG locus (Pro12Ala, C1431T). Heights and
weights were measured. Energy intake from a test meal was measured
90 min after ingestion of a no-energy (NE), low-energy (LE),
or high-energy (HE) preload, and the compensation index(COMPX)
was calculated.
Results: BMI differed significantly by gene model, whereby
Pro12Ala was associated with a lower BMI. Poor COMPX was
associated with the PPARG T1431 allele (P 0.009). There was a
significant interaction between COMPX and the ADRB3 Trp64Arg
variant in modulating compensation (P 0.003), whereas the Arg64
allele was associated with good compensation (P 0.001).
Conclusions: This is the first study to suggest that a genetic interaction
involving ADRB3 and PPARG variants influences eating behavior
in children.
Description
Citation : Cecil, J.E., Palmer, C.N.A., Fischer, B., Watt, P., Wallis, D.J., Murrie, I.S.L., and Hetherington, M.M. (2007) Variants of the peroxisome proliferator-activated receptor g- and b-adrenergic receptor genes are associated with measures of compensatory eating behaviors in young children. American Journal of Clinical Nutrition, 86, pp. 167-173
Peer Reviewed : Yes