Presented in this chapter are data on the principal hydrolysis products of Russian VX (RVX) with excess and equimolar quantity of water, as well as a generalized list of compounds extracted from samples of construction materials of a former RVX production facility. Toxicokinetic experiments have been conducted to determine decrease of O-alkyl methylphosphonates in blood plasma of rats after i.m. administration of RVX. MS/MS peptide spectra obtained with commercially available human albumin incubated with RVX revealed covalent binding of RVX to Tyr 411 and Tyr150. A new covalent adduct of N,N-diethyl-2-aminoethanthiol (a RVX hydrolysis product) with blood plasma proteins has been detected by HPLC–MS/MS, and this can be another marker of exposure to RVX. New data on effects developed under chronic exposure of rats to RVX are presented: these are kinetic parameters of blood platelet aggregation and electrophysiology of Nervus tibialis. According to these data, morphofunctional changes at the level of the microcirculatory bed may prove to be a significant factor in the etiology of delayed effects.
Citation:Rembovskiy, V. et al. (2015) Russian VX. In: Gupta, R.C. ed Handbook of the Toxicology of Chemical Warfare Agents. 2nd edition, Elsevier: Oxford, pp. 111-130