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dc.contributor.authorJacob, D.en
dc.contributor.authorTaylor, M. Joanen
dc.contributor.authorTomlins, P.en
dc.contributor.authorSahota, T. S.en
dc.contributor.authorJaroszkiewicz, E.en
dc.date.accessioned2014-08-15T10:24:21Z
dc.date.available2014-08-15T10:24:21Z
dc.date.issued2014-07
dc.identifier.citationJacob, D. et al. (2014) Diffusion of fluorescent insulin from an acrylic derivatised dextran-concanavalin A gel in an implantable closed loop insulin delivery device. 41st Controlled Release Society Annual Symposium, Chicago, USAen
dc.identifier.urihttp://hdl.handle.net/2086/10199
dc.descriptionD Jacob peer reviewed abstract accepted for poster presentation at 41st Controlled Release Society, Chicago, USAen
dc.description.abstractThe drug delivery mechanism of fluorescently labelled fluorescein isothiocyanate insulin (FITC-insulin) from a glucose responsive gel held in an implantable closed loop insulin delivery device was found to be diffusion controlled. The diffusion coefficient of FITC-insulin in the gel was determined and response to glucose challenges assessed. In response to physiologically relevant glucose challenges in the NP gel, the diffusivity of FITC-insulin increases with increasing glucose concentrations, showing a second order polynomial fit, device thus showing glucose sensitivity and graded response, mimicking pancreas.en
dc.language.isoenen
dc.publisherControlled Release Soceityen
dc.subjectinsulinen
dc.subjectdiffusionen
dc.subjectimplasntable deviceen
dc.subjectDiabetesen
dc.titleDiffusion of fluorescent insulin from an acrylic derivatised dextran-concanavalin A gel in an implantable closed loop insulin delivery deviceen
dc.typeConferenceen
dc.peerreviewedYesen
dc.funderD Jacob is a PhD student funded by De Montfort Universityen
dc.projectid-en
dc.researchinstituteLeicester Institute for Pharmaceutical Innovation - From Molecules to Practice (LIPI)en


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