Browsing by Author "Vaudry, David"
Now showing items 1-3 of 3
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A novel mechanism of autophagic cell death in dystrophic muscle regulated by P2RX7 receptor large-pore formation and HSP90.
Young, Christopher N. J.; Sinadinos, Anthony; Lefebvre, Alexis; Chan, Philippe; Arkle, Stephen; Vaudry, David; Gorecki, Dariusz (Article)P2RX7 is an ATP-gated ion channel, which can also exhibit an open state with a considerably wider permeation. However, the functional significance of the movement of molecules through the large pore (LP) and the intracellular ... -
P2RX7 Purinoceptor: A Therapeutic Target for Ameliorating the Symptoms of Duchenne Muscular Dystrophy
Sinadinos, Anthony; Young, Christopher N. J.; Al-Khalidi, Rasha; Teti, Anna; Kalinski, Pawel; Mohamad, Shafini; Floriot, Léonore; Henry, Tiphaine; Tozzi, Gianluca; Jiang, Taiwen; Wurtz, Olivier; Lefebvre, Alexis; Shugay, Mikhail; Tong, Jie; Vaudry, David; Arkle, Stephen; doRego, Jean-Claude; Górecki, Dariusz (Article)Duchenne muscular dystrophy (DMD) is the most common inherited muscle disease, leading to severe disability and death in young men. Death is caused by the progressive degeneration of striated muscles aggravated by sterile ... -
Sustained activation of P2X7 induces MMP-2-evoked cleavage and functional purinoceptor inhibition.
Young, Christopher N. J.; Chira, Natalia; Rog, Justyna; Al-Khalidi, Rasha; Benard, Magalie; Galas, Ludovic; Chan, Philippe; Vaudry, David; Zabłocki, Krzysztof; Górecki, Dariusz C. (Article)P2X7 purinoceptor promotes survival or cytotoxicity depending on extracellular ATP (eATP) stimulus intensity controlling its ion channel or P2X7-dependent large pore (LP) functions. Mechanisms governing this operational ...