Browsing by Author "Quansah, Emmanuel"
Now showing items 1-5 of 5
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1H NMR-based metabolomics reveals neurochemical alterations in the brain of adolescent rats following acute methylphenidate administration
Quansah, Emmanuel; Ruiz-Rodado, Victor; Grootveld, M.; Probert, Fay; Zetterstrom, T. S. C. (Article)The psychostimulant methylphenidate (MPH) is increasingly used in the treatment of attention deficit hyperactivity disorder (ADHD). While there is little evidence for common brain pathology in ADHD, some studies suggest a ... -
Chronic methylphenidate preferentially alters catecholamine protein targets in the parietal cortex and ventral striatum
Zetterstrom, T. S. C.; Quansah, Emmanuel; Zette (Article)The psychostimulant methylphenidate (MPH) is the primary drug treatment for attention deficit hyperactivity disorder (ADHD) in children. MPH is well known to acutely block the dopamine (DAT) and noradrenaline (NET) ... -
Chronic methylphenidate regulates genes and proteins mediating neuroplasticity in the juvenile rat brain
Methylphenidate (MPH) is the front-line psychostimulant medication prescribed for alleviating the symptoms associated with attention deficit hyperactivity disorder (ADHD) in children. Here, we investigated the effects of ... -
Methylphenidate alters monoaminergic and metabolic pathways in the cerebellum of adolescent rats
Abnormalities in the cerebellar circuitry have been suggested to contribute to some of the symptoms associated with attention deficit hyperactivity disorder (ADHD). The psychostimulant methylphenidate (MPH) is the major ... -
Molecular and Neurochemical Effects of Methylphenidate on the Developing Brain
Quansah, Emmanuel (Thesis or dissertation / Doctoral / PhD)Attention deficit hyperactivity disorder (ADHD) affects 2.6-4.5% of the worlds population, with affected children often performing poorly at school. The catecholamine hypothesis of ADHD proposes that the disorder results ...