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Browsing by Author "Chaudhuri, Bhabatosh"
Now showing items 1-7 of 7
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Williams, Ibidapo Steven ; Chibnall, S. ; Nuthakki, V. ; Gatchie, Linda ; Joshi, Prashant ; Narkhede, N. ; Vishwakarma, R.A. ; Bharate, Sandip B. ; Saran, S. ; Chaudhuri, Bhabatosh (Article / Image, 3-D)Naturally occurring polyphenolic compounds are of medicinal importance because of their unique antioxidant, anticancer and chemopreventive properties. Baicalein, a naturally occurring polyhydroxy flavonoid possessing ...
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Siddique, Mohd Usman Mohd ; Sonawane, Vinay ; Horley, Neill ; Williams, Ibidapo Steven ; Joshi, Prashant ; Bharate, Sandip B. ; Jayaprakash,Venkatesan ; Sinha, Barij N. ; Chaudhuri, Bhabatosh ; McCann, Glen J. P. (Article)Highly selective CYP1B1 inhibitors have potential in the treatment of hormone-induced breast and prostate cancers. Mimicry of potent and selective CYP1B1 inhibitors, α-naphthoflavone and stilbenes, revealed that two ...
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Horley, Neill ; Beresford, Kenneth J. M. ; Chawla, Tarun ; McCann, Glen J. P. ; Ruparelia, K. C. ; Gatchie, Linda ; Sonawane, Vinay ; Williams, Vinay R. ; Tan, Hoon Leong ; Joshi, Prashant ; Bharate, Sonali S. ; Kumar, Vikas ; Bharate, Sandip B. ; Chaudhuri, Bhabatosh (Article)The structure of alpha-napthoflavone (ANF), a potent inhibitor of CYP1A1 and CYP1B1, mimics the structure of chalcones. Two potent CYP1B1 inhibitors 7k (DMU2105) and 6j (DMU2139) have been identified from two series of ...
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Horley, Neill ; Beresford, Kenneth J. M. ; Kaduskar, S. ; Joshi, Prashant ; McCann, Glen J. P. ; Ruparelia, K. C. ; Williams, Ibidapo Steven ; Gatchie, Linda ; Sonawane, Vinay ; Bharate, Sandip B. ; Chaudhuri, Bhabatosh (Article)The overexpression of CYP1 family of enzymes is reported to be associated with development of human carcinomas. It has been well reported that CYP1A1 specific inhibitors prevents carcinogenesis. Herein, thirteen pyridine-4-yl ...
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Sharma, Rajni ; Gatchie, Linda ; Williams, Ibidapo Steven ; Shreyans, K. J. ; Vishwakarma, R. A. ; Chaudhuri, Bhabatosh ; Bharate, Sandip B. (Article / Image, 3-D)The development of multi-drug resistance to existing anticancer drugs is one of the major challenges in cancer treatment. The over-expression of cytochrome P450 1B1 enzyme has been reported to cause resistance to cisplatin. ...
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Joshi, Prashant ; Sonawane, Vinay ; Williams, Ibidapo Steven ; McCann, Glen J. P. ; Gatchie, Linda ; Sharma, Rajni ; Satti, Naresh ; Chaudhuri, Bhabatosh ; Bharate, Sandip B. (Article)CYP1A1 is thought to mediate carcinogenesis in oral, lung and epithelial cancers. In order to identify a CYP1A1 inhibitor from an edible plant, 394 natural products in the IIIM's natural product repository were screened, ...
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Williams, Ibidapo Steven ; Joshi, Prashant ; Gatchie, Linda ; Sharma, M. ; Satti, N.K. ; Vishwakarma, R.A. ; Chaudhuri, Bhabatosh ; Bharate, Sandip B. (Article / Image, 3-D)Inhibitors of CYP1 enzymes may play vital roles in the prevention of cancer and overcoming chemo-resistance to anticancer drugs. In this letter, we report synthesis of twenty-three pyrrole based heterocyclic chalcones ...
Now showing items 1-7 of 7
