Browsing by Author "Chaudhuri, Bhabatosh"
Now showing items 1-7 of 7
-
Biotransformation of chrysin to baicalein: Selective C6- hydroxylation of 5,7-dihydroxyflavone using whole yeast cells stably expressing human CYP1A1 enzyme
Williams, Ibidapo Steven; Chib, Shifali; Nuthakki, V.; Gatchie, Linda; Joshi, Prashant; Narkhede, N.; Vishwakarma, R. A.; Bharate, Sandip B.; Saran, S.; Chaudhuri, Bhabatosh (Article)Naturally occurring polyphenolic compounds are of medicinal importance because of their unique antioxidant, anticancer and chemopreventive properties. Baicalein, a naturally occurring polyhydroxy flavonoid possessing ... -
Biphenyl urea derivatives as selective CYP1B1 inhibitors
Siddique, Mohd Usman Mohd; Sonawane, Vinay; Horley, Neill; Williams, Ibidapo Steven; Joshi, Prashant; Bharate, Sandip B.; Jayaprakash,Venkatesan; Sinha, Barij N.; Chaudhuri, Bhabatosh; McCann, Glen J. P. (Article)Highly selective CYP1B1 inhibitors have potential in the treatment of hormone-induced breast and prostate cancers. Mimicry of potent and selective CYP1B1 inhibitors, α-naphthoflavone and stilbenes, revealed that two ... -
Discovery and characterization of novel CYP1B1 inhibitors based on heterocyclic chalcones: Overcoming cisplatin resistance in CYP1B1-overexpressing lines
Horley, Neill; Beresford, Kenneth J. M.; Chawla, Tarun; McCann, Glen J. P.; Ruparelia, K. C.; Gatchie, Linda; Sonawane, Vinay; Williams, Vinay R.; Tan, Hoon Leong; Joshi, Prashant; Bharate, Sonali S.; Kumar, Vikas; Bharate, Sandip B.; Chaudhuri, Bhabatosh (Article)The structure of alpha-napthoflavone (ANF), a potent inhibitor of CYP1A1 and CYP1B1, mimics the structure of chalcones. Two potent CYP1B1 inhibitors 7k (DMU2105) and 6j (DMU2139) have been identified from two series of ... -
(E)-3-(3,4,5-Trimethoxyphenyl)-1-(pyridin-4-yl)prop-2-en-1-one, a heterocyclic chalconeis a potent and selectiveCYP1A1 inhibitor and cancerchemopreventative agent
Horley, Neill; Beresford, Kenneth J. M.; Kaduskar, S.; Joshi, Prashant; McCann, Glen J. P.; Ruparelia, K. C.; Williams, Ibidapo Steven; Gatchie, Linda; Sonawane, Vinay; Bharate, Sandip B.; Chaudhuri, Bhabatosh (Article)The overexpression of CYP1 family of enzymes is reported to be associated with development of human carcinomas. It has been well reported that CYP1A1 specific inhibitors prevents carcinogenesis. Herein, thirteen pyridine-4-yl ... -
Glycyrrhiza glabra extract and quercetin reverses cisplatin resistance in triple-negative MDA-MB-468 breast cancer cells via inhibition of cytochrome P450 1B1 enzyme
Sharma, Rajni; Gatchie, Linda; Williams, Ibidapo Steven; Shreyans, K. J.; Vishwakarma, R. A.; Chaudhuri, Bhabatosh; Bharate, Sandip B. (Article)The development of multi-drug resistance to existing anticancer drugs is one of the major challenges in cancer treatment. The over-expression of cytochrome P450 1B1 enzyme has been reported to cause resistance to cisplatin. ... -
Identification of karanjin isolated from the Indian beech tree as a potent CYP1 enzyme inhibitor with cellular efficacy via screening of a natural product repository
Joshi, Prashant; Sonawane, Vinay; Williams, Ibidapo Steven; McCann, Glen J. P.; Gatchie, Linda; Sharma, Rajni; Satti, Naresh; Chaudhuri, Bhabatosh; Bharate, Sandip B. (Article)CYP1A1 is thought to mediate carcinogenesis in oral, lung and epithelial cancers. In order to identify a CYP1A1 inhibitor from an edible plant, 394 natural products in the IIIM's natural product repository were screened, ... -
Synthesis and biological evaluation of pyrrole-based chalcones as CYP1 enzyme inhibitors, for possible prevention of cancer and overcoming cisplatin resistance
Williams, Ibidapo Steven; Joshi, Prashant; Gatchie, Linda; Sharma, M.; Satti, N. K.; Vishwakarma, R. A.; Chaudhuri, Bhabatosh; Bharate, Sandip B. (Article)Inhibitors of CYP1 enzymes may play vital roles in the prevention of cancer and overcoming chemo-resistance to anticancer drugs. In this letter, we report synthesis of twenty-three pyrrole based heterocyclic chalcones ...